? ? ? ? ? ? ? ? ? ? ? UDC ? ? ? ? ?-G ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? !“# $ 2009.04?%?2?ABC?DEFGHIJK ?$%+,?A?HC?DLM?NHBCOPQOK?+,-? ?RS-? LM?N?abc?def?gRhijkW-? ? ?lmno?pqo? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?rs1tuvwxy?cjz/|?o$%? ?Nq?24? 31? ? ? ? ? “35? IVF-ET ?+-SHLA-G ABCDEFG?H-IJ35? 1? KL35? 2? MN37? 3? OPQR41? 4? ST43? U? ? ? ? Q46? VW“(47? X?YZ89R56? ? ? ? ? 57? ? ? -. /0 1 2 34 2 567 ? 818? ? “#$?% ? AH?assisted?hatching?_ab? AI?artificial?insemination?cd? AID?artificial?insemination?by?donor?e?cd? AIH? artificial?insemination?with?husbands? sperm? fg?,?cd? ART?assisted?reproduction?teachnology?_.hij? bp?basepair?klm? CTL?cytotoxicity?t?lymphocyte?n? T op? DXR?delyed?xeno-transplantation?rejection?qrstuvwxy? DTH?delayedtype?hypersensitivity?qrzxy? EVT?vascular?endothelial?cells?|? GM-CSF? granulocyte?macrophage?colony? stimulating?factor? ? ,? HLA-A?humanleukocyteantigen?-?A? A? HLA-B?humanleukocyteantigen?-?B? B? HLA-C?humanleukocyteantigen?-?C? C? HLA-G?humanleukocyteantigen?-G? G? Hc?heavy?chains? ICP?intrahepatic?cholestasis?of?pregnancy? ? ? -. /0 1 2 34 2 567 ? 828? ICSI?intracytoplasmic?sperm?injection? ?,? ? IFN-?interferon-? ILT?immunoglobulin-like?transcript?34? IVF?in?vitro?fertilization? IVF-ET?in?vitro?fertilization-embryo?transfer? IVM?in?vitro?maturation?,? IUGR?intrauterine?growth?retardation?rq? KIR?killer?cell?inhibitory?receptors?“? LIF?leukaemia?inhibitory?factor? ?fi ?,? LGL?1arge?granular?lymphocyte? fl ?op? MHA?major?histocompatibility?antigen?$? MHC?majorhistocompatibilitycomplex?$?/? mHLA-G?membrane-bound?HLA-G?Q?s HLA-G? NK?nature?killing?cell?“? NKR?nature?killing?cell?receptor?“? PAECs?pulmonary?artery?endothelial?cells?”? PBMC?peripheml?blood?mononuclear?cell?X? PGD?preimplantation?genertic?diagnosis? ?G?sHLA?G?6I?6?!?9: sHLA?G -. /0 1 2 34 2 567 ? 858? ?/C?6-A?0+?“u_? ?0BC-Dc?E(? F89GH9: IVF ?6?I78 -?6?! sHLA?G -J/?KSD?L?(?- A? ?-?9:GH?_.hij?ART?IVF?-?D6?! ? G?sHLA?G?-AB?KS sHLA?G E IVF FG? ?H-IJ? MN? ?33M 4 7 N?33M 4 ? N?OPQR.h!S:T? ?IVF?ET?-U?V?D?X6?-6?GH ELISA N9:6?! sHLA?G -WX? QR? ?6? EIVF?ET -?5H?I?_m?0BCMN-FG A?(W?)*FG?H? ? ? ? ? -. /0 1 2 34 2 567 ? 8478? ./()% 1?Geraghty?DE,?Koller?BH,?Orr?HT,?et?al?A?human?major?histocompatibility? complex?class?I?gene?that?encodes?a?protein?with?a?shortened?cytoplasmic? segment.Proc?NatlAcad?Sci?USAJ.?Proceedings?of?the?National?Academy? of?Sciences?of?the?United?States?of?America,1987,84(24):9145-9.? 2?Ellis?SA,?Sargent?IL,?Redman?CW,?et?al.?Evidence?for?a?novel?HLA?antigen? found?on?human?extravillous?trophoblast?and?a?choriocarcinoma?cell?line.? Immunology?J.Immunology,?1986,?59(4):?595-601.? 3?Jurisicova?A,?Casper?RF,?MacLusky?NJ,?et?al.?Embryonic?human?leukocyte? antigen-G? expression:possible? implications? for? human? preimplantation? developmentJ.?Fertil?Steril,1996,65(5):997-1002.? 4?Menicucci?A,?Noci?I,?Fuzzi?B,?et?al.?Non-classic?sHLA?class?I?in?human? oocyte?culture?medium.?Human?Immunol?1999,60:?1054.? 5?Fuzzi?B,?Rizzo?R,?Criscuoli?L,?et?al.?HLA-G?expression?in?early?embryos?is? a?fundamental?