oT08Z石婧圆陈燕忠吕竹芬【K1】M,0d?Zvs00_#ed04ZE,081p9。yz3M、3V#f08。T08Z8,o、Io#o。【1oM】o;08ColagenMicroparticlesinDrugDeliverySHIJing-yuan, CHENYan-zhong,LVZhu-fen.InstituteofPhar-maceuticalSciences,GuangdongColegeofPharmacy,Guangzhou510006,China【Abstract】Targetingdeliveryandcontrolledreleasedevicesformacromoleculardrugsdeliverymakeabigchalengetomicroparticledrugdeliverysystem, especialythedrugcarriers.Colagenisaninterestingnatu-ralmaterialforthepreparationofmicroparticles.Theattractivenessofcolagenrestsonitshighbiocompatibilityandlowimmunogenicity.Thisarticlehighlightscollagenmicroparticles presentstatusasacarrierindrugde-livery,including:colagen-coatedmicrospheres, thepreparationofcolagenmicroparticlesandcollagencompos-ites.【Keywords】Colagenmicroparticles;DrugcarrierT:510006T10。To5VC%!。VI,),zG?。?0ZT,g、i18。o?,3VV,9VYV“”%。i,f7,fQGi。5,d4|q2%-4%。V,Q=V,V1M;iOV_,VQ(V820。-,T0o)。“”B#4|/yF/m,|,?8。ID 1BeltingM, WitrupA.Macromoleculardrugdelivery:basicprinci-plesandtherapeuticapplications.MolBiotechnol, 2009, 43:89-94. 2KohaneDS.Microparticlesandnanoparticlesfordrugdelivery.BiotechnolBioeng, 2007, 96:203-209. 3ChanBP, HuiTY, YeungCW, etal.Self-assembledcolagen-hu-manmesenchymalstemcelmicrospheresforregenerativemedi-cine.Biomaterials, 2007, 28:4652-4666. 4HongY, GaoC, XieY, etal.Colagen-coatedpolylactidemicro-spheresaschondrocytemicrocariers.Biomaterials, 2005, 26:6305-6313. 5HufakerRK, MuirTW, RaoA, etal.Histologicresponseofpor-cinecolagen-coatedanduncoatedpolypropylenegraftsinarabbitvaginamodel.AmJObstetGynecol, 2008, 198:582,e1-7. 6OlsenD, YangC, BodoM, etal.Recombinantcolagenandgelat-infordrugdelivery.AdvDrugDelivRev, 2003, 55:1547-1567. 7ChangSJ, KuoSM, ManousakasI, etal.Preparationandcharac-terizationofhyaluronan/collagenImicrospheresunderanelectro-staticfieldsystemwithdiscelectrodes.ActaBiomater, 2009, 5:101-114. 8HsuFY, TsaiSW, WangFF, etal.Thecolagen-containingalgi-nate/poly(L-lysine)/alginatemicrocapsules.ArtifCelsBloodSub-230SC02010M345ChinJModDrugAppl,Mar2010,Vol.4,No.5stitImmobilBiotechnol, 2000, 28:147-154. 9ErdoganD, vanGulikTM.Evolutionoffibrinogen-coatedcolagenpatchforuseasatopicalhemostaticagent.JBiomedMaterResBApplBiomater, 2008, 85:272-278. 10RosslerB, KreuterJ, SchererD.Colagenmicroparticles:prepa-rationandproperties.JMicroencapsul, 1995, 12:49-57. 11RosslerB, KreuterJ, RossG.Efectofcollagenmicroparticlesonthestabilityofretinolanditsabsorptionintohairlessmouseskininvitro.Pharmazie, 1994, 49:175-179. 12ChengH, TsuiY, CheungKM, etal.Decelularizationofchon-drocyte-encapsulatedcollagenmicrospheres-A3Dmodeltostudyefectsofacelularmatrixonstemcelfate.TissueEngPartCMethods, 2009. 13Elron-GrossI, GlucksamY, BitonIE, etal.AnovelDiclofenac-carrierforlocaltreatmentofosteoarthritisapplyinglive-animalMRI.JControlRelease, 2009, 135:65-70. 14TsaiSW, ChenCC, LiouHM, etal.Preparationandcharacter-izationofmicrospherescomprisedofcollagen, chondroitinsulfate,andapatiteascariersfortheosteoblast-likecelMG63.JBiomedMaterResA, 2009. 15ChanOC, SoKF, ChanBP.Fabricationofnano-fibrouscolagenmicrospheresforproteindeliveryandefectsofphotochemicalcrosslinkingonreleasekinetics.JControlRelease, 2008, 129:135-143. 16AishwaryaS, MahalakshmiS, SehgalPK.Colagen-coatedpoly-caprolactonemicroparticlesasacontroleddrugdeliverysystem.JMicroencapsul, 2008, 25:298-306. 17SchlappM, FriessW.Colagen/PLGAmicroparticlecompositesforlocalcontroleddeliveryofgentamicin.JPharmSci, 2003, 92:2145-2151. 18LeeM, LoAC, CheungPT, etal.Drugcariersystemsbasedoncolagen-alginatecompositestructuresforimprovingtheperform-anceofGDNF-secretingHEK293 cels.Biomaterials, 2009, 30:1214-1221. 19ChowdhuryDK, MitraAK.Kineticsofinvitroreleaseofamodelnucleosidedeoxyuridinefromcrosslinkedinsolublecolagenandcolagen-gelatinmicrospheres.IntJPharm, 1999, 193:113-122. 20LynnAK, YannasIV, BonfieldW.Antigenicityandimmunoge-nicityofcollagen.JBiomedMaterResBApplBiomater, 2004,71:343-354.3miD5)李爱新【K1】Fmi5,eD。ZEmi5VV?/D5ys,|?4mieMZEn。TFmi58,remiD