DIABETES MELLITUSXuefeng Yu (余学锋Division of Endocrinology, Department of I DEFINITIONDiabetes mellitus is a group of metabolic disecharacterized by hyperglycemia resulting froin insulin secretion, insulin action, or bothThe deficient action of insulin on target tissue Acute, life-threatening consequences of undiabetes are hyperglycemia with ketoacidononketotic hyperosmolar syndrome.The chronic hyperglycemia of diabetes is awith long-term damage, dysfunction, and f ChronicComplication(1)MicropathyDiabetic retinopathy糖尿病视网膜病变成年人致盲的首要原因Diabetic nephropathy糖尿病肾病终末期肾病的首要原因2 ChronicComplication(1)1.Eye: retinopathy with potential loss of2.Kidney: nephropathy leading to renal3.Nerves:Peripheral neuropathy with risk of