1Analysis of Geranium leaves the heart through the soft capsule molding processAbstract Objective: To determine orientin leaves the heart through the best soft capsule molding process. Methods: A single-factor method of parallel testing of materials and their dosage, the capsule material, production molding temperature was filtered results: the optimum is the amount of soybean oil as a suspension, and add beeswax suspending agents (2%), the first melt in the soybean oil, after cooling to room temperature, add essential oil mix, then add dry mixture of cream powder mixed with oil sufficient ground uniform (the ratio of 1:0.5 - 1:0.75), the use of gelatin: glycerol: water (mass ratio 1:0.4:1) as the capsule material, melt temperature at 70 80 , holding temperature at 55 65 when the system into soft gelatin capsules. Conclusion: This molding process is reasonable, stable, easy to operate, suitable for mass production. Keywords red Polygonum; soft capsule; beeswax; oil; orientin leaves the heart through the soft 2capsule Abstract Objective: To optimize the shaping technology of Hongyexintong soft capsules. Methods: Single factor parallel experimental method was adopted to screen the shaping processes in terms of adjuvant category and amount, material of capsule, and processing temperatures. Results: The optimized shaping process was as follows: Sufficient amount of soybean oil was added with beeswax (2%), cooled to room temperature after the beeswax being melted by heating. The oil mixture was blended with naphtha and dried extracts in the ratio range of 1:0.5 1:0.75 and shaped. The materials and ratio that formed the capsule hull were glutin: glycerol: water = 1:0.4:1. The gel-thawing temperature was 70 80 , and the shaping temperature 55 65 . Conclusion: The shaping process is reproducible and applicable to Hongyexintong soft capsules production in large scale. Keywords: Polygonum orientale; soft capsules; ceraflava; oils; Hongyexintong Soft Capsules Geranium leaves the heart through the soft capsule from the private prescription by orientin and many other herbs, usually in 3soups medicine for the treatment of chest pain, chest tightness, shortness of breath and other evidence of coronary heart disease angina blood stasis due to the existence decoction carry, taking inconvenient, difficult to control quality and other shortcomings, the clinical application is limited. for the preparation of stable quality control, clinical use of safe, effective, storage, transport, carry, easy to use dosage form, according to the characteristics of materials containing volatile components, the The bioavailability was prepared, the content is accurate, to avoid loss of volatile components evaporate, to cover up bad odor, easy to take a good look soft capsules, in order to improve the stability of formulations and patient compliance 1,2 At the same time, taking into account the collapse of the soft capsule shell in the body after the absorption of drugs to the rapid dispersion, in line with the treatment of angina pectoris rapid onset of drug characteristics, in line with the clinical application of new drugs, three-way, three small, five will be principles. Apparatus and materials 1.1 Instruments 4HRS-100-type soft capsule machine (Beijing Technology Co., Ltd. Oriental wisdom of God); METTLER AE240 electronic balance. 1.2 Materials Orientin, hawthorn leaves and extracts of Panax, Chuanxiong volatile components from the Guiyang Medical College, Center for Drug Research and Development, Central soybean leaves from Guangzhou Pharmaceutical Co., Ltd. production, production of gelatin from the North Gelatin Co., Ltd., Zhejiang, then by the glycerol Chang glycerine plant, beeswax from the Yangtze River in Nanchang pharmaceutical production. 2 Methods and Results 2.1 the choice of materials As a soft capsule and drug suspension mixed media materials must have good liquidity to ensure that large-scale production, but the mixture must have a good physical stability of the suspension medium is the most commonly used vegetable oil or vegetable oil plus non-ionic surface active agents or PEG400, etc. 3,4 Therefore, the choice of soybean oil as a suspension, 5adding beeswax as suspending agents and the ratio of the amount of materials and its province. 2.1.1 choose the amount of soybean oil In order to meet the needs of the production of soft capsules, pharmaceutical semi-finished products made from soybean oil in the suspension added to request a certain mobility, not too thin, to minimize the dose, so the need to dry paste powder and essential oil (semi-finished drugs), large study the proportion of soybean oil. to take drugs and semi-finished products of soybean oil mixing ratio respectively 1:0.25,1:0.5,1:0.75,1:1,1:1.25 to observe the flow of liquid and homogeneous results, see Table 1 Table 1 semi-finished products and soybean oil ratio test results (omitted) Note: T