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中华哮喘杂志(电子版)2013年12月第7卷第6期Chin J Asthma(Electronic Edition),December 2013,Vo17,No6 57 10Huang SK,Wettlaufer SH,Chung J,et a1Prostaglandin E2 inhibits specific lung fibroblast functions via selective actions of PKA and Epac1Am J Respir Cell Mol Biol,2008,39: 17 482489 11 12 13 14 15 16 Haag S,Warnken M,Juergens UR,et a1Role of Epacl in mediating antiproliferative effects of prostanoid EP(2) receptors and cAMP in human lung fibroblastsNaunyn Schmiedebergs Arch Pharmacol,2008,378:617-630 Roscioni SS,Dekkers BG,Prins AG,et a1cAMP inhihits modulation of airway smooth muscle phenotype via the exchange protein activated by cAMP(Epac)and protein kinase aBr J Pharmacol,2011,162:193209 Roscioni SS,Prins AG,Elzinga CR,et a1Protein kinase A and the exchange protein directly activated by cAMP(Epac) modulate phenotype plasticity in human airway smooth muscleBr J Pharmacol,2011,164:958969 Roscioni SS,Maarsingh H,Elzinga CR,et a1Epac as a nove1 effector of airway smooth muscle relaxationJ Cel1 Mo1 Med,2011,15:15511563 Zieba BJ,Artamonov MV,JIN Li,et a1The cAMP responsive Rap1 guanine nucleotide exchange factor,Epac, induces smooth muscle relaxation by downregulation of RhoA activityJ Biol Chem,2011,286:1668116692 Lyle KS,Raaijmakers JH,Bruinsma W,et a1cAMP induced EpacRap activation inhibits epithelial cell migration 18 19 2O 21 22 by modulating focal adhesion and leading edge dynamicsCell Signal,2008,20:11041116 Birukova AA,Zagranichnaya T,Alekseeva E,et a1Epac rap and PKA are nove1 mechanisms of ANPinduced rac mediated pulmonary endothelial barrier protectionJ Cell Physiol,2008,215:715 724 Jing D,Liang J,Fan J,et a1Regulation of lung injury and repair by Tolllike receptors and hyaluronanNat Med,2005, 11:1173 1179 Scheibner KA,Boodoo S,Collins S,et a1The adenosine a2a receptor inhibits matrix induced inflammation in a novel fashionAm J Respir Cell Mol Biol,2009,40:251-259 Sands WA,Woolson HD,Milne GR,et a1Exchange protein activated by cyclic AMP(Epac)一mediated induction of suppressor of cytokine signaling 3(SOCS-3)in vascular endothelial cellsMol Cel1 Biol,2006,26:63336346 Zhang A,Dong Z,Yang TProstaglandin D2 inhibits TGF beta1induced epithelialtomesenchymal transition in MDCK cellsAm J Physiol Renal Physiol,2006,291:F1332一F1342 Zhang A,Wang MH,Dong Z,et a1Prostaglandin E2 is a potent inhibitorof epithelialto mesenchymal transition: interaction with hepatocyte growth factorAm J Physiol Renal Physiol,2006,291:F1323一F1331 (收稿日期:2012-0820) 韩曙光,赵弘卿Epac:新的支气管哮喘治疗靶分子JCD中华哮喘杂志:电子版,2013,7(6):448451 急诊气道管理已出版 消 息 人民军医出版社最近出版急诊气道管理,George Kovacs和JAdam Law主编,刘双、朱光发主译,全 书共20章,涵盖了紧急情况下气道管理的所有问题。本书翻译的目的就是希望让麻醉医师意外的临床医师 (包括急诊医师、呼吸科医师、监护仪式、内科医师、外科医师、儿科医师、护士以及基层医务工作者)了解紧急 情况下处理气道的相关知识,掌握气道解剖、生理以及各种气管插管的设备和操作方法。该书是美国临床医 师继续教育的一本使用的权威教科书。 各地新华社及医学专业书店有售,定价每本42元。
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