xiemufengsina.com “ ” “ ” “ ” “ ” “ ” “ ” “ ” “ 1 2 3 4 ; Tablet pH (dyne/cm2) 1.2 - 7.6 35 - 50 (ml) pH (mmHg) pH (mM) (ml/min) 5 - 200 3.1 - 6.7 3 - 30 5.2 - 6.0 0 - 17 0 - 280 2001 0 20 40 60 10 20 30 40 50 60 70 (%) 1984 1989-1994 1995-1999 1 2 A B ? ? 哪 “ ” 0.0 0.5 1.0 1.5 2.0 2.5 3.0 3.5 02 04 06 08 01 0 0 % dissolved at 2 hr Cmax (ng/ml) 0.0 0.5 1.0 1.5 2.0 2.5 3.0 3.5 02 04 06 08 01 0 0 % dissolved at 2 hr Cmax (ng/ml) Cmax (1) pH = 1.2 (2) pH = 4.0 (3) pH = 6.8 (4) (SGF) (SIF) “ ” “ ” 0.0 0.2 0.4 0.6 0.8 0 20 40 60 80 100 0 20 40 60 80 100 A B pH = 1.0 0.0 0.2 0.4 0.6 0.8 A B pH = 4.0 0 20 40 60 80 100 02 04 06 0 Time