亚洲人关于脂类的多方面问题亚洲人关于脂类的多方面问题Ze Yang, Jan Dorman 231:661 Brown ML, Hesler C, Tall AR. Plasma enzymes and transfer proteins in cholesterol metabolism, Curr Opin Lipidol 1990;1:122 Swenson TL. The role of the cholesteryl ester transfer protein in lipoprotein metabolism. Diabetes Metab Rev 1991;7:139 Hesler CB, Swenson TL, Tall AR purification and characterization of a human plasma cholesteryl ester transfer protein. J Biol Chem 1987;262:2275 Ritter MC, Bagdade JD: Contribution of glyucaemic control, endogenous lipoproteins and cholesteryl ester transfer protein to accelerated cholesteryl ester transfer in IDDM. Eur J Clin Invest 1994; 24:607-614 关于胆固醇酯转移蛋白的参考文献 （续）Kahri J, Syvanne M, Taskinen M_R: Plasma cholesteryl ester transfer protein activity in non-insulin-dependent diabetic patients with and without coronary artery disease. Metabolism 1994;43:1498-1502 8. Richard J. Jones, Daphne Owens, Cara Brennan, Patrick B. Collins, Alan H. Johnson, Gerald H. Tomkin: Increased esterification of cholesterol and transfer of cholesteryl ester to apo B-containing lipoproteins in Type 2 diabetes: relationship to serum lipoproteins A-I and A-II. Atherosclerosis 1996; 119:151-157 Dennis Drayna, Alisha Stephens Jarnagin, John Mclean, William Henzel, William Kohr, Christopher Fielding 327:632-634 Luis B Agellon, Elaine M Quinet, Thomas G Gillette, Dennis T Drayna, Maryanne L Brown, Alan R Tail. Organization of the human cholesteryl ester transfer protein gene. Biochemistry 1990;29:1372-1376 关于胆固醇酯转移蛋白的参考文献 （续）Omar L Francone, Lori Royer, Mehrdad Haghpassand. Increased pre*- HSL levels, cholesterol efflux, and LCAT-mediated esterification in mice expressing the human cholesteryl ester transfer protein and human apolipoprotein A-I transgenes. J Lipid Res 1996;37:1268-1277 Jan Albert Kuivenhoven, Peter de Knijff, Jolanda MA Boer, Harold A Smalheer, Gert-Jan Botma, Jaap C Seidell, John JP Kastelein, P Haydn Pritchard. Heterogeneity at the CETP gene locus influence on plasma CETP concentrations and HDL cholesterol levels. Arterioscler Thromb Vasc Biol 1997;17:560-568 Harukuni Akita, Hitoshi Chiba, Keiko Tsuchihashi, Masahiro Tsuji, Mitsuru Kumagai, Kazuhiko Matsuno, Kunihiko Kobayashi. Cholesteryl ester transfer protein gene: two common mutations and their effect on plasma high-density lipoprotein cholesterol content. J Clin Endocrinol Metab 1994;79:1615-1618 Harukuni Akita, Hitoshi Chiba, Shu-Ping Hui, Yukihiro Takahashi, Kazuhiko Matsuno, Kunihiko Kobayashi. Cholesteryl ester transfer protein deficiency: identification in the Chinese. Am J Med Genet 1995;59:399-400 关于胆固醇酯转移蛋白的参考文献 （续）Shu-Ping Hui. Frequency and effect on plasma lipoprotein metabolism of a mutation in the cholesteryl ester transfer protein gene in the Chinese. 北海道医志 1997;72:319-327 Robin PF Dullaart, Klaas Hoogenberg, Stephen C Riemens, Johanna EM Groener, Arie van Tol, Wim J Sluiter, Ben K Stulp. Cholesteryl ester transfer protein gene polymorphism is a determinant of HDL cholesterol and of the lipoprotein response to a lipid-lowering diet in type 1 diabetes. Diabetes 1997;46:2082- 2087 Minna Tamminen, Sakari Kakko, Y Antero Kesaniemi, Markku J Savolainen. A polymorphic site in the 3* untranslated region of the cholesteryl ester transfer protein gene is associated with low CETP activity. Atherosclerosis 1996;124:237-247 Ukkola O, Savolainen Mj, Salmela PI, von Dickhoff K, Kesaniemi YA: DNA polymorphism at the locus for human cholesteryl ester transfer protein are associated with macro- and microangiopathy in non-insulin-dependent diabetes mellitus. Clin Genetics 1994;46:217-227 脂蛋白(a)（Lp(a)） 脂蛋白(a)是一种与冠心病有关的独立作用 的强效危险因子 脂蛋白(a)由载脂蛋白(a)（apo(a)）和载 脂蛋白(B100)之间的二硫键连接 因为载脂蛋白(a)与血纤蛋白溶酶原结构类 似，所以脂蛋白(a)具有凝血酶原的活性 有报道说如果血清中的脂蛋白(a)浓度大于 20mg/dl，2型糖尿病患者就很容易得冠心 病关于脂蛋白(a)的参考文献 Armstrong VW, Cremer P, Eberle E, Manke A, Shulze F, Wieland H, Kreuzer H, Seidel D. The association between serum Lp(a) concentrations and angiographically assessed coronary atherosclerosis. Atherosclerosis 1986;62:249 Fless GM, Zummallen ME, Scanu AM. Isolation of apolipoprotein (a) from lipoprotein (a). J Lipid Res 1985;26:1224-1229 Rath M, Neindorf A, Reblin T, Dietel M, Krebber H-J, Beisiegel U. Detection and quantification of lipoprotein(a) in the arterial wall of 107 coronary bypass patients. Arteriosclerosis 1989;9:579 关于脂蛋白(a)的参考文献（续） Mclean JW, cDNA sequence of human apolioprotein(a) is homologous to plasminogen. Nature. 1987;330:132-137 Kennel WB,D*Agostin RB, Wilson PW, Belanger AJ, Gagnon DR. Diabetes, fibrinogen, risk of cardiovascular disease: the Framingham experience. Am Heart J 1990;120:672 Eriko Morishita, Hidesaku Asakura, Hiroshi Jokaji, Masanori Saito, Chika Uotani, Ichiro Kumabashiri, Masahide Yamazaki, Keiji Aoshima, Takuma Hashimoto, Tamotsu Matsuda. Hypercoagulability and high lipoprotein(a) levels in patients with type II diabetes mellitus. Atherosclerosis 1996;120:7