唐朝枢北京大学医学部生理与病理生理学系北大医院临床医学研究所内质网应乏薯文处M计mmretculamstessERS)胡2木林育江EE朋0汀J江河人112JE22沥2广i命5Eiona林ER内环境的穗定是实现ER功能的保证,ERS反应实际上一种E2固醇代谢医E朐启动凋亡Ea人标(Nuclearsignaling)E不EEEndoplasmicReticulumStressintheHeartaChristopherC.Glembotski.Circ.Res.2007;101:975-984E沥一二i出内质网从而在其腔内聚集所致的细胞器之间E蛋白质在内质网j圆2沥应是激活转录因子NF-xB,与ERS时Caz+贮释DnssE着LEumammaliancellsZhaoLH,etal.CurrentOpinioninCellBiology2006;18:444-452。ProteintraffickingfromtheERraamermeatoeMtoddMALHOTRAJD,etalANTIOXIDANTS&REDOXSIGNALING:2007;9(12:2277-2293(国口吴0EE明iE腾白1口伟c口activatingprotein(SCAP)。ERS时在BR膜应江刀口丿林与SCAP形成复合物,进而被酶解成为转录吴口林医一扬E吴命剧ERstresssignalingpathWwayCellDeathandDitterentiation.2006;13:363-373MammalianresponsepathWaySforERStressi