Corneal diseaseGeneralFunctions1.cornea and sclera make up the external wall2.important refraction substance:+43D， 3/4 of the total refractive power3.no blood vesselImmune privilegeTransparent corneaEpithelium Basal cells Bowman membraneStromaDescemet membraneEndotheliumKeratitisEtiology1.infectivity : bacteria、fungi、virus、 acantha amoeba2. endogenetic:3. spread:Pathobiology causative agent infiltration transparentcorneal ulcer descemetocele corneal perforationnebula macula corneal scar corneal fistulaleucoma Adhesiveness keratoleukomaglaucomacorneal staphylomapanophthalmitisatrophia bulbi（眼球萎缩）clinical manifestationSymptom: ophthalmalgia、photophobia 、tearing、spasm of eyelid、secretion、 sight descentSign: ciliary congestion、corneal infiltration、corneal ulcerDiagnose Symptom + Sign laboratory examinationTherapy Remove etiological factor Control infection Promote healing Decrease cicatricleBacterial keratitis Etiologycorneal traumapathogenic bacteriapartly&systemic factors