许田教授：How to Give Oral Presentations11月9日（星期日）11月3日（星期一） 顾玉东院士：怎样做临床科研11月10日（星期一） 袁钧瑛教授：科研与合作8:50（306教室）邯郸校区正门内8:00有车前来韩启德院士：漫谈研究生的成长问题 1:30 pm（12-30）教室新视野系列研究生课程：科技论文的构思、撰写和发表 生物医学世纪讲坛How to Publish Your Papers in the Top Scientific Journals鲁白 教授鲁白教授1957年12月生于上海市。1982年获上海华东师范大学学士学位。1990年获康乃尔大学博士学位后，在洛克菲勒大学和哥伦比亚大学从事博士后研究,导师为Paul Greengard和蒲慕明教授。1993年加入罗氏分子生物学研究所，并任哥伦比亚大学助理教授。1996年加入NIH儿童健康和人类发育研究所，任突触发育和可塑性研究室主任。主要研究神经营养因子在突触发育和可塑性中的作用。他的研究室是最早提出并发现神经营养因子对神经系统突触传递、突触发育可塑性有调控作用的实验室之一，与几个著名实验室一起开创了神经营养因子的突触调控这一新领域。Bai Lu 怎 样样 在 国 际际 权权 威 杂杂 志 上 发发 表 科 学 论论 文 鲁 白鲁 迅 Lu Xun (1881-1936)The father of modern Chinese literaturesThe most influential poet in Chinese history李 白 Li Bai (701-762)1.M. F. Egan, M. Kojima, J. H. Callicott, T. E. Goldberg, B. S. Kolachana, E. Zaistev, A. Bertolino, B. Gold, D. Goldman, M. Dean, B. Lu, (co-corresponding author) and D. R. Weinberger. (2003) The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 112, 257-269. 2.L. Ma, Y. -Z. Huang, J. Valtschanoff, L. Feng, B. Lu, W. Xiong, R. Weinberg, L. Mei. (2003) Ligand- dependent recruitment of the neuregulin signaling complex into neuronal lipid rafts. J. Neurosci. 23, 3164- 3175. 3.J. Wang, C. -Q. Chen, B. Lu, and C. -P. Wu. (2003) GDNF acutely potentiates Ca2+ channels and excitatory synaptic transmission in midbrain dopaminergic neurons. NeuroSignals 12, 78-88. 4.M. Miura, S. Gronthos, M. Zhao, B. Lu, L. W. Fisher, P. G. Robey, and S. Shi (2003) SHED: Stem cells from human exfoliated deciduous teeth. Proc. Natl. Acad. Sci. USA 100, 5807-5812. 5.Y. X. Zhou, M. Zhao, K. Shimazu, K. Sakata, D. Li, C. -X. Deng, B. Lu. (2003) Impairments in cerebellum Purkinje cells and motor function in mice lacking Smad4 in the central nervous system. J. Biol. Chem. 278, 42313 - 42320. 6.J. Du, L. Feng, E. Zaitsev, H. S. Je, X. Liu, and B. Lu. (2003) Activity- and tyrosine kinase-dependent facilitation of TrkB receptor internalization in hippocampal neurons. J Cell Biol. In press. 7.Z. G. Luo, H. -S. Je, F. Yang, W. C. Xiong, B. Lu, and L. Mei (2003) Activation of geranylgenanyltransferase is essential for Agrin-induced AChR clustering. Neuron In press. 8.S. X. Bamji, K. Shimazu, N. Kimes, J. Huelsken, W. Birchmeier, B. Lu, L. F. Reichardt. (2003) Regulation of presynaptic assembly and maintenance by -catenin. Neuron In Press. 9.F. Yang, X. He, J. Russell, and B. Lu. (2003) Ca2+ influx independent transmitter release mediated by mitochondrial Na+-Ca2+ exchanger and protein kinase C. J. Cell Biol. In press. 2003 research articlesWhat Is the Purpose of Doing Research?It is not about the number of papersIt is not about the number of papersIt is not about the impact factor of the papers It is not about the impact factor of the papersIt is not about the Nobel Prize It is not about the Nobel Prize Publish or perishPublish or perish1 Nature = 10 JBC1 Nature = 10 JBCBasic Elements for Basic ResearchPassionPassion6 6 SigmaSigmaSilver bullet testSilver bullet testGood Research Is the Keyn nMy English is not goodMy English is not goodn nThey are biased against Chinese (foreigners)They are biased against Chinese (foreigners)n n人家没做过人家没做过 你就要做你就要做n n这是新的这是新的 = = 这是好的这是好的What Is a First-Class Paper/Research?n nMajor advance in a classic fieldMajor advance in a classic field干细胞是如何分化成特定组织细胞的，胆固醇在人体的正常功用干细胞是如何分化成特定组织细胞的，胆固醇在人体的正常功用n nNew techniques and methods that can be widely usedNew techniques and methods that can be widely used人类基因组研究中的自动测序技术人类基因组研究中的自动测序技术 , , PCR, Patch clamp, Ca2+ PCR, Patch clamp, Ca2+ Imaging, GFPImaging, GFPn nDiscoveries with obvious practical implications Discoveries with obvious practical implicationsAIDS virus receptor AIDS virus receptor 的发现的发现, , 老年痴呆症基因的发现老年痴呆症基因的发现 n nConceptual breakthrough, novel ideasConceptual breakthrough, novel ideas神经营养因子可以促进学习记忆神经营养因子可以促进学习记忆, , RNARNA干干扰现扰现扰现扰现 象象 n nChallenge to traditional views, break dogmaChallenge to traditional views, break dogma脑内有可分裂的神经干细胞，打破了传统观念脑内有可分裂的神经干细胞，打破了传统观念 n nOpening up new area, cross boardOpening up new area, cross board“细胞凋亡细胞凋亡”现象的发现现象的发现, , 开辟了新的科研领域开辟了新的科研领域 What Is a Mediocre Paper/Research? Horizontal growthI made the discovery in rats, you find the same in cat. Filling gapsEGF activates JNK which is known to induce c-Jun expression. You show that EFG enhances c-Jun expression. Working out detailsI found NO induces the production of cGMP, you work out dose response and time course. Support existing idea, “me too”EGF-R endocytosis requires dynamin, PDGF-R too. Follow up CREB binds to CRE. Working out CRE sequence. Incomplete study, preliminaryHow to Read Scientific Papers? The Gilbert way Keep these in mind when you read What is the major question addressed in this paper? Is this question important and why? What are the approaches used in this paper, and whether they are adequate for the questions? What are the novel idea