1Molecular Diagnosis of GI Cancer上有意Ji9EEHSEBeeom奋大学消化疾病研究所厅市消化疾病中心a VOLUMET9TNUMER5TNMAY 0 NATORENEDICINE Serum trefoil factor 3 is a biomarker and predictor of responses to chemotherapyin gastrointestinal cancersLi Xiaol. Yun-Peng Liul.Chuan-Xing Xiaol, Jian-Lin Ren” and Bayasi Gulen:Department of Gastroenterology, Zhongshan Hospital affiliated to Xiamen University201 Hubin South Road, Xiamen, Fuiian PIGvinee. China. 361004METHODS: Serum and urine samples were collected from 90 patients with gastriccancer， 128 patients with colorectal cancer and 91 healthy individuals as a controlgroup. Serun and urine TFF3 levels were measured using an ELISA Serum levels of TFF3 were significantly elevatedin both gastric and colorectal cancer patientsserum TFF3|次Cafe GasmEcaneerSensitivity全上和已1- speafialtySerumTFF3PoaootSensitivityAuc-0819Core coancia cancerSerum TFF3 (ngiml)1- Specificiy Urine levels of TFF3 were significantly elevatedin both gastric and colorectal cancer patientsUnine TFF3Peooool 。Auc=o874Sensitivityine TFF3重光Peoooo时SensitivityAUC-0.805C三呈所E生和d量量尼癌=皇和control 。 Colorectal cancer1- Specificity 区TU让TiP=0.0074P=0.041 P=0.010830 多3 ( 三司所CDLLLL加皇了8忌由由Serum TF |With the clinical stage (l-I vs IV) and distant metastasis Serum levels as a prognostic marker for colorectal cancerHigher serum TFF3 levelwas Significantly correlatedRE 本: 训介|一 vs IV) and distantmetastasis，Older patientsos114 人 昌 (age 60 y) were higherthan the levels of; differentlymphatic昌 包 电 号可所PP吧加上SE50 StageHll Stagelll Stago和Pat786多和 Serum TFF3 (ngiml)和Serum TFF3 (ngiml) Ages60 。 Age 60Serum TFF3 (ngiml) ET让本we二chemotherapy in gastric and colorectal cancer PR patientsFig. 4引Gastric Cancer Colorectal Cancer圈 PD图 PR 人 Serum level of JTB灾必风 P0.0001Gastric Colon 13 3 LE肠癌血清检测 无淋巴结转移 淋巴结转移 远处转移