Responding to Pain by Marcia Zimmerman Chronic Pain Encompasses several distinct entities; eg. Headache, TMJ Arthritis Fibromyalgia Chronic muscle pain Involves physical and psychological stress, loss of function, quality of life, employment and income, prolonged litigation, loss of work productivity, medical costs Treating Pain Limited effectiveness of conventional treatments Alternative therpies are sought by many CAM therapies sought include Chiropractic (54%) and massage (38%) Acupuncture Meditation Tai chi We are the only creatures on earth who can change our biology by what we think and feel. THE PAST “It is Incomprehensive That Our Thoughts Can Move Molecules” Sir John Eccles - Parapsychologist Our Thoughts CREATE MOLECULES THE PRESENT The Atom Basic structure of universe Energy makes it vibrate; in a precise rhythm Links into molecules Molecules vibrate in response to energy and chemical cues. Cells Cells vibrate with energy Surface receptors wiggle, shake, and hum Bend back and forth changing shapes Scanning for messages Thoughts, sounds are messages Generating Positive Feelings Creating increased order in the autonomic nervous system produces beneficial effects throughout the body- including enhanced immunity (1) and improved hormonal balance (2) 1.Rein, G., Atkinson, M., and McCraty, R. The physiological and psychological effects of compassion and anger. Journal of Advancement in Medicine. 1995; (2):87-105 2.McCraty, R., Atkinson, M., Rein, G. and others. Music enhances the effects of positive emotional states on salivary IgA. Stress Medicine. 1996;12:167-175 Psychoneuroimmunology (PNI) PASTEliminate StressFUTURE Stay in the NOW Decreases stress, balanced healthy Brain, nerves, immune and hormone response Cortisol DHEA Meditation, prayer, brain sync tapes/books, music, dance, yoga, etc. Biochemical Communication Through Hormones PrePost 25 20 15 10 5 0 Cortisol PrePost 10 8 6 4 2 0 DHEA Doc Childre and Howard Martin with Donna Beech The HearthMath Solution 1999: 205 nM ng/ml Exercise and Physical Therapy Exercise Induces endorphin release Improves circulation, aerobic capacity Reduces Cortisol, increases DHEA Examples Walking, swimming, yoga, Qi gong, Tai chi, dance, all exercises that engage the mind Physical therapy Range of motion Strength gains Improves functionality Omega 6sOmega 3s LA GLA DGLA AASeries 1 Series 2 ALA EPA Series 3 DHA EFAs and Inflammation Elastase and Elongase enzymes Series 2 Prostanoids AACell Membrane CyclooxygenaseLipoxygenase COX2 COX1LTB4 Cytosol free radicals attack AA Inflammatory Response Series 2 prostanoids PGE2, inflammation ?, B.P. ?, sodium ? LTB4, congregation of WBCs, free radicals COX2, inflammation, pain Immune Cells Macrophages & T-Cells IL-1, IL-6, TNF?, ? inflammation Memory T-Cells, auto-reactive Oxidative stress Immune Cells Macrophages T-Lymphocytes IL-1 Oxygen Free Radicals IL-6 TNF ? HOW NATURAL PAIN KILLERS WORK Arachidonic acid 5-lipoxygenase Boswellic acids NSAIDs block Cox 1,2 Cyclooxygenase Pycnogenol Membrane Cytosol Curcumin, Green Tea, Resveratrol COX2COX1 Astaxanthin, beta carotene block inflammatory genes Free Radicals Omega-3s block AA entry into cell 0 0.2 0.4 0.6 0.8 1 1.2 1.4 1.6 ZANTSyn. AVit. ETocosCaroteneLuteinLycopene Relative Antioxidant Activity Contributed by Le Haye Labs, mfgs. Of ZANTHIN brand astaxanthin Boswellin Resin of frankincense, boswellic acids Unique effects: Blocks 5-lipoxygenase (leukotriene bio- synthesis) Human leukocyte elastase Anti-inflammatory effects Curcumin Active ingredient in turmeric Blocks 5-lipoxygenase and cyclooxygenase in human platelets Inhibits NF-kappa B activation Foods That Cause Pain ? Alcohol ? Caffeine ? Coffee ? Tea ? Dairy Products ? Carbonated Beverages ? Meat ? Solanaceae (arthritis) ? Wine ? Sugar ? Aspartame ? White Flour ? Wheat ? Nuts ? Citrus ? Margarine ? MSG ? Aged Cheese Foods That Ease Pain ?Spelt, teff, quinoa ?Barley, oats, millet ?Dark, leafy greens ?Fruit (except citrus) ?Legumes ?Rice ?Red, yellow, orange, green vegetables ?Fish (salmon, tuna, anchoives, bluefish, herring, sardines, sturgeon, mackerel, lake trout) ?Flaxseed, canola and walnut oils The Gluten Syndrome Neurological Condition Adverse effects on nervous system (ataxia, developmental delay, learning disorders, depression, migraine, and headaches) May or may not involve the gut Gluten Containing Foods Wheat (bread, pasta, cereals) Barley Rye Teff Spelt Couscous Bulgar wheat Seitan Kamut Malt vinegar Maltodextrin (wheat source) Soy & Teriyaki sauce Some beer Gluten Safe Foods Oats (wheat-free facility) Corn Rice Quinoa Amaranth Legumes Soy (wheat-free facility) Gut Feelings Brain/Gut Axis Independent enteric nervous system Interacts with CNS Bi-directional communication between them Involves neural pathw