精品文档 免费阅读 免费分享 如需请下载！ 请下载！ 关于疫苗安全的关于疫苗安全的 补充信息补充信息 第 2 部分：免疫接种后的 不良事件基础发生率 疫苗和生物制品司疫苗和生物制品司 世界卫生组织 日内瓦 2000年 ii 疫苗和生物制品司疫苗和生物制品司 感谢提供非特定经济支持的捐助者，感谢提供非特定经济支持的捐助者， 他们的支持使之有可能出版这份文件。他们的支持使之有可能出版这份文件。 有些数据来自原先由世界卫生组织 西太平洋区域办事处扩大免疫规划编写的材料 本文件由疫苗和生物制品司 扩大免疫规划处编写 C.J. Clements 博士编辑博士编辑 订购编号：WHO/V family history of convulsions and use of antipyretics. MMWR: Morbidity and Mortality Weekly Report, 36:2812. CDC (1996) Centers for Disease Control and Prevention. Advisory Committee on Immunization Practices (ACIP). Update: vaccine side effects, adverse reactions, contraindications and precautions. MMWR: Morbidity and Mortality Weekly Report, 45(RR-12):2231. CDC (1997). Centers for Disease Control and Prevention. Advisory Committee on Immunization Practices (ACIP). Pertussis Vaccination: Use of acellular pertussis vaccines among Infants and young children. MMWR: Morbidity and Mortality Weekly Report, 46(RR-7):116. Cherry JD (1996). Historical review of pertussis and the classical vaccine. Journal of Infectious Diseases, 174,supt 3:S259S263. Cody CL, Baraff LJ, Cherry JD, et al. (1981). Nature and rates of adverse reactions associated with DTP and DT immunizations in infants and children. Pediatrics, 68:650 60. Decker MM, Edwards KM, Steinhoff MC, et al. (1995). Comparison of 13 acellular pertussis vaccines: adverse reactions. Pediatrics, 96:55766. Decker MM, Edwards KM (1996). The multicenter acellular pertussis trial: An overview. Journal of Infectious Diseases, 174, supt 3:S270S275. Edsall G, Altman JS, Gaspar AJ (1954). Combined tetanus-diphtheria immunization of adults: Use of small doses of diphtheria toxoid. American Journal of Public Health, 44:153745. Edwards KM, Decker MD, Mortimer Jr EA (1999). Pertussis vaccine. In Plotkin S, Orenstein W, eds. Vaccines, 3rd ed., WB Saunders Company, 1999:293-344. WER (1982). Expanded Programme on Immunization. Reactions to tetanus toxoid. Weekly Epidemiological Record, 57:1934. Farrington P, Pugh S, Colville A et al. (1995). A new method for active surveillance of adverse events from DTP and MMR vaccines. Lancet, 345: 5679. 24免疫接种后的不良事件基础发生率 Feldman S, Perry S, Andrew M, et al. (1992). Comparison of acellular (B type) and whole-cell pertussis component diphtheria-tetanus-pertussis vaccines as the first booster immunization in 1524 month-old children. Journal of Pediatrics, 121:85761. Gupta RK, Relyveld EH (1991). Adverse reactions after injection of adsorbed diphtheria-pertussis-tetanus (DPT) vaccine are not due only to pertussis organisms or pertussis components in the vaccine. Vaccine, 9:abstract. Gustafsson L, Hallander HO, Olin P, et al. (1996). A controlled trial of a two- component acellular, a five-component acellular, and a whole-cell pertussis vaccine. New England Journal of Medicine, 334:34955. Halperin SA, Eastwood BJ, Barreto L, et al. (1996). Adverse reactions and antibody response to four doses of acellular or whole cell pertussis vaccine combined with diphtheria and tetanus toxoids in the first 19 months of life. Vaccine, 14:76772. Ipp MM et al. (1987). Acetaminophen prophylaxis of adverse reactions following vaccination of infants with diphtheria-pertussis-tetanus toxoids-polio vaccine. Pediatric Infectious Disease Journal, 6:7215. Ipp MM, Gold R, Goldbach M, et al. (1989). Adverse reactions to diphtheria, tetanus, pertussis-polio vaccination at 18 months of age: effect of injection site and needle length. Pediatrics, 83:67982. Livengood JR, Mullen JR, White JW, et al. (1989). Family history of convulsions and use of pertussis vaccine. Journal of Pediatrics, 115:52731. Long S, Deforest A, Smith DG, et al. (1990). Longitudinal study of adverse reactions following diphtheria-tetanus-pertussis vaccine in infancy. Pediatrics, 85:294302. Mark A, Carlsson RM, Granstrom M (1999). Subcutaneous versus intramuscular injection for booster DT vaccination of adolescents. Vaccine, 17:206772. Mills E, Gold R, Thipphawong J, et al (1998). Safety and immunogenicity of a combined five-component pertussis-diphtheria-tetanus-inactivated poliomyelitis-Haemophilus b conjugate vaccine administered to infants at two, four and six months of age. Vaccine, 16:57685. Mortimer Jr EA, Kharton M (1999). Diphtheria toxoid. in Plotkin S, Orenstein W. Vaccines, 3rd ed. Philadelphia, PA, WB Saunders Company, 1999:140157. Myers MG, Beckman CW, Vosdingh RA et al. (1982). Primary immunization with tetanus and diphtheria toxoids. Reactions rate and immunogenicity in older children and adults. JAMA: The Journal of the American Medical Association, 248:247880. WHO/V 104:3436. Barry DW, Mayner RE, Hochstein HD, et al (1976). Comparative trial of influenza vaccines. II. Adverse reactions in children and adults. American Journal of Epidemiology, 104:4759. Bierman CW, Shapiro GG, Pierson WE, et al. (1997). Safety of influenza vaccine in allergic children. Journal of Infectious Diseases, 136:S652S655. WHO/V 181(1):215-21. WHO/V Kemp 等, 1990; James 等, 1995）。因此，蛋过敏史不再被