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雅思考试备考复习模拟试题 人的知识愈广,人的本身也愈臻完善。以下是为大家搜索整理的雅思考试备考复习模拟试题20XX,希望能给大家带来帮助!更多精彩内容请及时关注我们应届! 1.Thefailureofahigh-profilecholesteroldrughasthrownaspotlightontheplicatedmachinerythatregulatescholesterollevels.Butmanyresearchersremainconfidentthatdrugstoboostlevelsofgoodcholesterolarestilloneofthemostpromisingmeanstobatspirallingheartdisease. 2.DrugpanyPfizerannouncedon2Decemberthatitwascancellingallclinicaltrialsoftorcetrapib,adrugdesignedtoraiseheart-protectivehigh-densitylipoproteins(HDLs)。Inatrialof15000patients,asafetyboardfoundthatmorepeoplediedorsufferedcardiovascularproblemsaftertakingthedrugplusacholesterol-loweringstatinthanthoseinacontrolgroupwhotookthestatinalone. 3.Thenewscameasakickintheteethtomanycardiologistsbecauseearliertestsinanimalsandpeoplesuggesteditwouldlowerratesofcardiovasculardisease.“Therehavebeennoredflagstomyknowledge,”saysJohnChapman,aspecialistinlipoproteinsandatherosclerosisattheNationalInstituteforHealthandMedicalResearch(INSERM)inPariswhohasalsostudiedtorcetrapib.“Thiscancellationcameasapleteshock.” 4.TorcetrapibisoneofthemostadvancedofanewbreedofdrugsdesignedtoraiselevelsofHDLs,whichferrycholesteroloutofartery-cloggingplaquestotheliverforremovalfromthebody.Specifically,torcetrapibblocksaproteincalledcholesterolestertransferprotein(CETP),whichnormallytransfersthecholesterolfromhigh-densitylipoproteinstolowdensity,plaque-promotingones.Statins,incontrast,mainlyworkbyloweringthebadlow-densitylipoproteins. Underpressure 5.Researchersarenowtryingtoworkoutwhyandhowthedrugbackfired,somethingthatwillnotbeeclearuntiltheclinicaldetailsarereleasedbyPfizer.Onehintliesinevidencefromearliertrialsthatitslightlyraisesbloodpressureinsomepatients.Itwasthoughtthatthismildproblemwouldbeoffsetbytheheartbenefitsofthedrug.Butitispossiblethatitactuallyprovedfatalinsomepatientswhoalreadysufferedhighbloodpressure.Ifbloodpressureistheexplanation,itwouldactuallybegoodnewsfordrugdevelopersbecauseitsuggeststhattheproblemsarespecifictothispound.OtherprototypedrugsthatarebeingdevelopedtoblockCETPworkinaslightlydifferentwayandmightnotsufferthesamedownfall. 6.ButitisalsopossiblethatthewholeideaofblockingCETPisflawed,saysMotiKashyap,whodirectsatherosclerosisresearchattheVAMedicalCenterinLongBeach,California.WhenHDLsexcretecholesterolintheliver,theyactuallyrelyonLDLsforpartofthisprocess.SoinhibitingCETP,whichpreventsthetransferofcholesterolfromHDLtoLDL,mightactuallycauseanabnormalandirreversibleaccumulationofcholesterolinthebody.“Youreblockingaphysiologicmechanismtoeliminatecholesterolandeffectivelyconstipatingthepathway,”saysKashyap. Goingup 7.Mostresearchersremainconfidentthatelevatinghighdensitylipoproteinslevelsbyonemeansoranotherisoneofthebestroutesforhelpingheartdiseasepatients.ButHDLsareplexandnotentirelyunderstood.Oneapproveddrug,calledniacin,isknowntobothraiseHDLandcecardiovascularriskbutalsocausesanunpleasantsensationofheatandtingling.Researchersareexploringwhethertheycanbypassthissideeffectandwhetherniacincanlowerdiseaseriskmorethanstatinsalone.Scientistsarealsoworkingonseveralothermeanstobumpuphigh-densitylipoproteinsby,forexample,introducingsyntheticHDLs.“Theonlythingweknowisdeadinthewateristorcetrapib,notthewholeideaofraisingHDL,”saysMichaelMiller,directorofpreventivecardiologyattheUniversityofMarylandMedicalCenter,Baltimore. Questions1-7 Thispassagehas7paragraphs1-7. Choosethecorrectheadingforeachparagraphfromthelistofheadingsbelow. Writethecorrectnumberi-ixinboxes1-7onyouranswersheet. ListofHeadings i.Howdoestorcetrapibwork? ii.Contradictoryresultpriortothecurrenttrial iii.Onefailuremaypossiblybringaboutfuturesuccess iv.Thefailuredoesntleadtototallossofconfidence v.Itistherightroutetofollow vi.Whyitsstopped vii.Theymaybineandtheoreticallyproduceidealresult viii.Whatswrongwiththedrug ix.Itmightbewrongatthefirstplace Questions7-13 Matchtorcetrapib,HDLs,statinandCETPwiththeirfunctions(Questions8-13)。 WritethecorrectletterA,B,CorDinboxes8-13onyouranswersheet. NBYoumayuseanylettermorethanonce. 7.Ithasbeenadministeredtoover10,000subjectsinaclinicaltrial. 8.Itcouldhelpridhumanbodyofcholesterol. 9.Researchersareyettofindmoreaboutit. 10.Itwasusedtocethelevelofcholesterol. 11.AccordingtoKashyap,itmightleadtounwantedresultifitsblocked. 12.Itproducedcontradictoryresultsindifferenttrials. 13.ItcouldinhibitLDLs. Listofchoices A.Torcetrapic B.HDLS C.Statin D.CETP SuggestedAnswersandExplanations 1.vi 2.ii 3.vii本段介绍了torcetrapib和statin的治病原理,但是同时短语“incontrast”与之前第二段后半段的内容呼应,暗示了这两种药在理论上能相辅相成,是理想的搭配。第一个选项无法涵盖整段意义,故选择i是错误的。 4.iii本段分析了可能导致torcetrapibl临床试验失败的原因,后半段指出如果以上推测正确,那么未来的药物可借鉴这个试验,设法避免torcetrapib的缺陷,研制出有效的药物。viii选项无法涵盖后半段的意思。 5.ix见首句。 6.v 7.A见第二段。题目中administer一词意为“用药”,subject一词为
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