The Clinical Significance of Nuclear YAP Expression in Hepatocellular Carcinoma徐 智南京医科大学附属南京第一医院暨南京市第一医院 肿瘤内科1Worldwide incidence of HCCBlum HE, Spangenberg HC. Arch Iran Med. 2007 Jul;10(3):361-71.Identification of Yes-associated Protein (YAP)Zender, L. et al. Cell 125, 1253-67EFGHYAP improves cell proliferationTime (Days)*：p0.05。 YAP induces anchorage-independent growthMIHA-YAP cells but not MIHA-Vec could form colonies in soft-agar.MIHA-YAP cells gained advantages in cell migration and invasion.YAP enhances cellular mobility and invasivenessIHC results of YAP in HCC53.7% HCC samples showed nuclear YAP positive.Clinical association of nuclear YAP in HCCClinical association of nuclear YAP and HCC-specific postsurgical recurrenceKaplan-Meier Median RFT：Nuclear YAP negative: 25.8 months vs. Nuclear YAP positive：12.9 monthsNuclear YAP is an independent prognostic marker for HCC recurrenceCox Regression SummaryYAP confers tumorigenic and metastatic potentials in hepatocytes, as evidenced by enhanced aptitudes in cell viability, anchorage-independent growth, migration and invasion. YAP nuclear accumulation was found in the 53.7% of HCC, correlated with poorer tumor differentiation and higher serum alpha-fetoprotein (AFP) levels. Nuclear YAP is an independent predictor for HCC-specific recurrence-free survival. YAP plays an important role in HCC development and progression. Acknowledgement新加坡国立大学外科系和药学系 Asso. Prof. John M. Luk香港大学外科系 Prof. Fan S. T.，Prof. Poon R. T. and Surgical Tissue Bank南京市第一医院肿瘤内科