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The Clinical Significance of Nuclear YAP Expression in Hepatocellular Carcinoma徐 智南京医科大学附属南京第一医院暨南京市第一医院 肿瘤内科1Worldwide incidence of HCCBlum HE, Spangenberg HC. Arch Iran Med. 2007 Jul;10(3):361-71.Identification of Yes-associated Protein (YAP)Zender, L. et al. Cell 125, 1253-67EFGHYAP improves cell proliferationTime (Days)*:p0.05。 YAP induces anchorage-independent growthMIHA-YAP cells but not MIHA-Vec could form colonies in soft-agar.MIHA-YAP cells gained advantages in cell migration and invasion.YAP enhances cellular mobility and invasivenessIHC results of YAP in HCC53.7% HCC samples showed nuclear YAP positive.Clinical association of nuclear YAP in HCCClinical association of nuclear YAP and HCC-specific postsurgical recurrenceKaplan-Meier Median RFT:Nuclear YAP negative: 25.8 months vs. Nuclear YAP positive:12.9 monthsNuclear YAP is an independent prognostic marker for HCC recurrenceCox Regression SummaryYAP confers tumorigenic and metastatic potentials in hepatocytes, as evidenced by enhanced aptitudes in cell viability, anchorage-independent growth, migration and invasion. YAP nuclear accumulation was found in the 53.7% of HCC, correlated with poorer tumor differentiation and higher serum alpha-fetoprotein (AFP) levels. Nuclear YAP is an independent predictor for HCC-specific recurrence-free survival. YAP plays an important role in HCC development and progression. Acknowledgement新加坡国立大学外科系和药学系 Asso. Prof. John M. Luk香港大学外科系 Prof. Fan S. T.,Prof. Poon R. T. and Surgical Tissue Bank南京市第一医院肿瘤内科
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