DirectoryRichard BrunoAssociate Professor, Human NutritionRichard Brunos Vitae325 Campbell Hall Campbell Hall(614) 292-5522bruno.27osu.eduDoctorate of Philosophy in Human Nutrition, Ohio State University; Columbus, OhioMaster of Science in Human Nutrition, University of Delaware; Newark, DelawareBachelor of Science in Applied Nutrition; Minor in Biology, University of Delaware; Newark, DelawareResearch InterestsDr. Richard Bruno is a bionutritionist and registered dietitian with expertise in the areas of phytochemical and antioxidant utilization and metabolism in relation to free radical-mediated toxicology. The research conducted in his laboratory aims to define the mechanisms regulating the bioavailability of phytochemicals, particularly vitamin E and polyphenols, and the mechanisms by which these dietary agents protect against oxidative stress and pro-inflammatory responses that otherwise contribute to vascular endothelial dysfunction and nonalcoholic steatohepatitis (NASH). His work routinely utilizes obese experimental models and clinical populations having heightened oxidative stress and inflammatory responses with the underlying goal of translating experimental findings into practical recommendations that promote optimal health in humans.At present, studies led by his laboratory are directed at:1 Improving the bioavailability of quercetin using dietary manipulations and quercetin-nanoemulsions,2 Defining -tocopherol bioavailability and dietary requirements in individuals with metabolic syndrome,3 Identifying the antioxidant and anti-inflammatory mechanisms of green tea during NASH,4 Defining the vasoprotective activities of -tocopherol supplementation during smoking cessation, and5 Determining the vasoprotective activities of dairy ingestion in individuals with metabolic syndrome.GrantsGreen Tea Confections For Managing Postprandial Hyperglycemia-Induced Vascular Endothelial DysfunctionSponsor: The Ohio State University Food Innovation Center (2013-2014) The goal of this product is to develop a novel green tea catechin containing confection that aims to attenuate postprandial blood glucose and its associated effects that induce vascular endothelial dysfunction Anti-Inflammatory Activities Of Green Tea During Obesity-Induced NASHSponsor: Ohio Agricultural Research Development Center (2013-2015) The goal of this project is to better define the hepatoprotective mechanisms by which green tea suppresses NFB activation in a diet-induced obese model of NASH. Dairy Fat as a Mediator of Vitamin E Adequacy in Individuals with Metabolic SyndromeSponsor: Dairy Research Initiative (2012-2015)The goal of this project is to define -tocopherol bioavailability in response to dairy fat and evaluate dietary vitamin E requirements in individuals with metabolic syndrome. Vasoprotective Activities of Low-Fat Milk in Individuals with Metabolic SyndromeSponsor: Dairy Research Institute (2011-2013)The goal of this project is to define the acute vasoprotective effects of low-fat milk ingestion on postprandial changes in vascular endothelial function and nitric oxide homeostasis in individuals with metabolic syndrome. Cardioprotective Synergy of Smoking Cessation and -Tocopherol in Restoring Vascular Endothelial FunctionSponsor: Connecticut Department of Public Health (2011-2013)The goal of this project is to examine the extent to which dietary -tocopherol supplementation improves vascular function in combination with smoking cessation by lowering oxidative stress and pro-inflammatory responsesPublicationsSW Leonard*, RS Bruno*, E Paterson, BC Schock, J Atkinson, TM Bray, CE Cross, MG Traber. (2003). 5-Nitro-gamma-tocopherol increases in human plasma exposed to cigarette smoke in vitro and in vivo. Free Radic Biol Med, 35 (12): 1560-7. *Both authors contributed equallyRS Bruno, R Ramakrishnan, TJ Montine, TM Bray, MG Traber. (2005). alpha-Tocopherol disappearance is faster in cigarette smokers and is inversely related to their ascorbic acid status. Am J Clin Nutr; 81(1): 95-103.RS Brunoand MG Traber. (2005). Cigarette smoke alters human vitamin E requirements. J Nutr; 135(4): 671-4 (Invited Review).RS Bruno, SW Leonard, J Li, TM Bray, MG Traber. (2005). Lower plasma alpha-carboxyethyl-hydroxychroman after deuterium labeled alpha-tocopherol supplementation suggests decreased vitamin E metabolism in smokers. Am J Clin Nutr; 81(5): 1052-9. (Publication named by the NIH to the Top 25 Dietary Supplementation studies for 2005).RS Bruno, SW Leonard, R Ramakrishnan, J Atkinson, TJ Montine, TM Bray, MG Traber. (2006). Faster plasma vitamin E disappearance in smokers is normalized by vitamin C supplementation. Free Radic Biol Med; 40(4):689-97; Epub Nov 15 2005. (Received commentary: Buettner GR. (2006). Commentary on Faster plasma vitamin E disappearance in smokers is normalized by vitamin C supplementation. Free Radic