HUMAN MOLECULAR GENETICS (BIOL 506) Fall 2005Professor:Dr. George MouradText Book:Human Molecular Genetics 3Strachan T., Read A.P.Third Edition 2004Garland PublishingOffice:Science Building, Room 380 Phone:481-5704E-mail:mouradipfw.eduURL:http:/users.ipfw.edu/mourad/Courses/courses.htmOffice Hours:Tuesday, 10:30 AM - 11:30 AMFriday, 3:00 PM - 4:00 PMOr by appointment Requirements:Genetics & Molecular Biology (BIOL 218) and one semester of organic chemistry or biochemistry.Objective: This is an upper-division course designed for undergraduate biology majors and graduate students. The course is quite useful to all professionals in biology interested in health-related areas as well as in basic fields of biology. In this course you will learn about a dynamic field that is expanding very rapidly and is directly concerning human biology and general health. The course deals with the mode of inheritance of human genes, structure and organization of the human genome, mapping of the human genome, the technology behind sequencing the human genome, instability of the human genome, human gene expression, identifying human disease genes, cancer genetics, genetic testing in individuals and populations, functional genomics, proteomics, bioinformatics, genetic manipulation of cells and animals, and new approaches to treating diseases (gene therapy).Reading of Prime Literature:Being an upper division course, each student will be assigned an original research paper to thoroughly read then present to the class. The student presentation will be for 15 minutes followed by 5 minutes of discussion. The latter will include questions from me and the students. Fifty points are allocated to your presentation and for answering questions from me and your class-mates. You are expected to contribute to the discussions of research articles presented by your colleagues.Grading Policy:There is a total of 400 points allocated for this course and distributed as follows:Exam I = 100 pointsExam II= 100 pointsExam III= 100 pointsPaper Presentation= 50 pointsInvolvement in Discussion of Papers = 50 points Attendance is expected and will be taken every lecture. It will be used only if you are at a border line (1%) between two grade categories. If you attended all the lectures and you are only 1% from a higher grade then I will move your grade to a higher category. This is a bonus that you should take advantage of. Schedule of LecturesDateTopicCh.Pages_ 8/23Introduction & review of DNA structure & gene expression11-328/25Chromosome structure & function 233-588/30Genes in pedigrees & populations4101-1209/1Continuation9/6Cell-based cloning5121-1529/8Nucleic acid hybridization: principles & applications6155-179 9/13Analyzing DNA, gene structure, variation & expression7181-2029/15How the human genome was mapped & sequenced8208-2299/20Organization of the human genome9239-2709/22Continuation/Research papers9/27Human gene expression10275-3109/29Exam I10/4Instability of the human genome: mutation & DNA repair11315-347 10/6Identifying human disease genes14415-43110/11Fall Break (Classes Off)10/13Continuation/Research papers10/18Molecular pathology16461-48310/20Cancer genetics17487-50410/25Genetic testing in individuals & populations18509-535*10/27Continuation/Research papers11/1Review11/3Exam II11/8Functional genomics, proteomics & bioinformatics19539-57211/10Continuation/Research papers11/15Genetic manipulation of cells & animals20576-60511/17Continuation/Research papers11/22New approaches to treating disease21610-62811/24Thanksgiving Recess (Classes Off)11/29Continuation/Research papers12/1Research papers12/6Research papers12/8Research papers12/13Final Exams Week (No Class)12/15Exam III (4:00 PM 6:00 PM)_*Last Day to Withdraw is October 28