文档供参考，可复制、编制，期待您的好评与关注！ 肺纤维化论文：多种药物对博来霉素诱导的大鼠肺纤维化的干预作用比较【中文摘要】比较地塞米松(dexamethasone, DXM)、N-乙酰半胱氨酸(N-acetylcysteine, NAC)、干扰素-(Interferon-gamma, IFN-y)、低分子量肝素(low molecular weight heparin, LMWH)对博来霉素(Bleomycin, BLM)诱导的大鼠肺纤维化的干预作用。方法：150只SD雄性大鼠随机分为健康对照组、肺纤维化模型组、地塞米松干预组、NAC干预组、IFN-干预组和LMWH干预组,每组25只。各组分别于第1、3、7、14、28天各处死5只,收集肺组织作切片行HE和Masson染色判断肺组织肺泡炎和肺纤维化程度,行免疫组化测定肺组织转化生长因子1 (transforming growth factor-1,TGF-1),收集血清和支气管肺泡灌洗液(bronchoalveolar lavage fluid, BALF)行ELISA检测TGF-1含量,收集肺组织检测羟脯氨酸(hydroxyproline,HYP)含量。结果：1.与模型组比较,四个药物干预组的肺泡炎及肺纤维化程度在第28天均明显减轻(.【英文摘要】:To investigate the role of dexamethasone,NAC,IFN-y and LMWH in suppressing bleomycin-induced pulmonary fibrosis in rats.Method:One hundred and fifty SD rats were randomly divided into six groups(25 rats in each group), ie. a normal group,a bleomycin-induced pulmonary fibrosis model group,a dexamethasone-treated group,a N-acetylcysteine-treated group,a Interferon-gamma-treated group,a low molecular weight heparin-treated group.Five rats in each group were randomly killed on lth day,3th day,7th .【关键词】肺纤维化 博来霉素 大鼠 转化生长因子1【英文关键词】pulmonary fibrosis bleomycin rats transforming growth factor-1【索购全文】联系Q1：138113721 Q2：139938848【目录】多种药物对博来霉素诱导的大鼠肺纤维化的干预作用比较英文缩略词5-7中文摘要7-9Abstract9-11引言12-14研究对象、试剂、仪器设备及方法14-21结果21-27附图27-35讨论35-39结论39-40参考文献40-45综述45-53参考文献50-53文章发表情况53-54致谢54 /