).JJ.lJ().().()DNA1953Watson,CrickDNA,38,DNA70DNA,DNA(),.,80,DNA,;,DNA,:,;,-DNA,-,_,DNA,RNA,DNA,mRNA,cDNA,(1),:N,NDNA.,-,246375,:,240Kb,195Kb,Hindlll16,DP;A50Kb,B30Kb,C20Kb,Cosm,DNASangerDNA,DNA,30060ont,50Kb.DNADNA,:ORFs,-.,-,HBsAg,DN,;.,.,(2)l(1),._DNA,HBVv,6,DNARNA,(2)._,.,:,;:10Obp1,ATTATAd,JL812bp(Upstreampromoterelements,UPEs)TATA,UPEs(3)UPEs:Uepolerelents,r-lTATA-J30bp-100boCcr.J1(UPEs)GGGGCGG(CCCGCCC),DNASP1,EZ,HIVILTR,HSVIIE1,IE3,IE4/5,HSVtK,SV4O;CCAAT,CTF/NF1NA,MuLV,2,MSVLTR,HSV1tK;GCCACACCC,SV40,TGCAAATTAATGARAT,DNANF,3.MTVLlRSV40,UPEsTATAUPETATA,-DNA,uPEs,SPI,CTF/NF1APz,JICP4mRNA10300bp,70150bp,-,.DNA,.,/,;,_I8bp,(4)(3)Kozak(5)211mRNA,ATG_,ATG3,A,1,2,45C,CCA/GCCAUG(G)Luetcke(6):,CACCAUG,AACAAUGGC(4),DNA,1,-,RNA,DNARNA2.RNARNARNAMSZ,3569,t,74%(37),RNA,AUG,:mRNA,-,RNA,RNA_3,ucU,ucA,ucc,ucG,AGu,AGc1DNADNADNADNADNA,