The Nobel Prize in Physiology or Medicine 1982Sune K BergstromBengt SamuelssonJohn R Vane1/3 of the prizeSwede nKarolinska Institutet Stockholm, Swedenb. 1916d. 20041/3 of the prizeSwede nKarolinska InstitutetStockholm, Swedenb. 19341/3 of the prizeUnited KingdomThe Wellcome Research Laboratories Beckenham, UnitedKin gdomb. 1927d. 2004for their discoveries concerning prostaglandins and related biologically active substances 1982年逹同辑番學獎俘主C左起 4妙曜、#旬潜苛壯和范思舉林互.竟Q1982年十月十一口星期一，位于瑞典斯德哥尔摩的卡洛琳斯卡研究院(Karol in ska Institute)正式宣布將本年诺贝尔生理医学奖給两位瑞典籍及一位英国籍的科学家，推 崇他們在前列腺素(prostagladin)方面的研究所作的贡献。这三位得奖者是英国的范恩 (J. R. Vane),五十五岁，现任英国威尔康研究所(Wellcome Research Laboratories) 主任；瑞典的塞缪尔森(B. Samuelsson),四十八岁，卡洛琳斯卡医学院院长及卡洛琳 斯卡研究院院长以及今年六十六岁的柏格斯壮(SBergstrom)。柏格斯壮博士同时还身 兼诺贝尔基金会的董事长，不过那只与基金会的行政业务有关，与得奖者的选拔过程无涉。Sune K. Bergstrom 一 AutobiographyI was born January 10th, 1916 in Stockholm, Sweden.1944D. Med. Sci., Biochemistry, KarolinskaInstituted Stockholm1946 47 Research Fellowship, Basel University, Basel1947 - 58 Professor of Physiological Chemistry, The University of Lund, Lund1958 - 80 Professor of Chemistry, Karolinska Institutet, Stockholm196366Dean of the Medical Faculty, Karolinska Institutet, Stockholm1969 - 77Rector of Karolinska Institutet, Stockholm1975 -Chairman of the Board of Directors, The NobelFoundation, Stockholm1982Nobel Laureate in Physiology or Medicine,Stockholm1983Preside nt of the Royal Swedish Academy ofSciencesJohn R. Vane - AutobiographyJohn R. Vane - AutobiographyJohn R. Vane - AutobiographyI was born in Halmstad, Sweden, on may 21, 1934.After attending public schools I studied medicine at the University of Lund where I met my wife Karin (Bergstein). We have one son (Bo) and two daughters (Elisabet and Astrid).After a few years in Lund I moved to Karolinska Institutet in Stockholm in order to do graduate work in biochemistry in parallel with medical studies.In 1960 I finished my dissertation and became docent in medical chemistry. A year later I also obtained my MD degree from Karolinska Institutet.In 1967 I was appointed professor of medical chemistry at the Royal Veterinary College in Stockholm, and after a few years I moved back to Karolinska Institutet to become professor and chairman of the department of physiological chemistry. Con currently with my research positions I have also held administrative posts.丨 was dean of the medical faculty from 1978 to 1983, and is presently rector of Karolinska Institutet.Memberships and HonorsMember of the Royal Swedish Academy of Sciences (1981)Foreign Honorary Member of the American Academy of Arts and Sciences (1982)Honorary Member, Swedish Medical Association, Stockholm, Sweden (1982)I was born in Tardebigg, Worcestershire, on the 29th March 1927, one of three children, with an elder sister and brother. My father, Maurice Vane, was a son of immigrants from Russia and my mother, Frances Vane, came from a Worcestershire farming family.At the age of 12, my parents gave me a chemistry set for Christmas and experimentation soon became a consuming passion in my life. Shortly afterwards, my father, who ran a small company making portable buildings, erected a wooden shed for me in the garden, fitted with bench, gas and water. This became my first real laboratory.In 1944 I move to the University of Birmingham to study Chemistry. However, the enthusiasm with which I had approached experimentation in Chemistry in the garden shed was soon dampened, for at university experimentation was nonexistent. At this stage that I began to realise that my interest lay not in chemistry but more in experimentation. Thus, when Maurice Stacey, the Professor of Chemistry, asked me what I wanted to do when 丨 graduated, I said anything but chemistry”. Stacey then told me that he had received a letter that morning from Professor Harold Burn in Oxford asking whether he could recommend another young chemist (he had sent one the previous year) to go to Oxford to be trained in pharmacology. Without hesitation I grasped the opportunity and immediately went to the library to find out what pharmacology was all about! That brief exchange with Stacey reshaped my whole career.I went to Burns department in 1946f anyone can be said to have moulded the subject of pharmacology around the world, it is he. His laboratory became the most active and important centre for pharmacological research in the U.K. and the main school for training of young pharmacologists .It was his en ergy and inspirati on that set my career into one of adventure in the fields of bioassay and pharmacologyAfter qualifying for a B.Sc. in pharmacology, I spent a few months in Sheffield University as a research worker in the pharmacology department but then went back to Oxford to the Nuffield Institute for M