第四章缩合反应练习题一、举例说明或解释以下人名反应。1. Mannich 反应2. Strecker反应3. Michael 反应4. Knoevenagel反应5. Perkin反应6. Stobbe反应7. Wttig 反应8. Darzens反应9. Diels-Alder 反应10. Aldol 缩合二、请选出下列反应的主产物。t-BuOKClCH2COOC2H5Ot-BuOH1.( )( )A.B.C.D.ClCHCOOC2H5ClCH2COOCH2COOC2H5ClCHCOOCHCOOC2H5CHCH2OOC2H5CHCH2OOC2H5OCHCOOC2H5OHClCHO浓NaOD/D2O+2.( )( )A.B.C.D.CH2OD+COONaCH2OH+COONaCH2OD+COOHCH2ONa+COONa(CH3)2CCHCHOOH3.( )A.B.C.D.(CH3)2CCHCH2CH2CCH3CHCHO(CH3)2CCHCH2CHCCH3CHCHOOH(CH3)2CCHCH2CH2CCH3CHCOOH(CH3)2CCHCHCHCCH3CHCHO+OO加热O4.( )精选学习资料 - - - - - - - - - 名师归纳总结 - - - - - - -第 1 页，共 9 页A.B.C.D.OOOOOOOOOOOOONaOEtEtOHOCHONa+()5.A.B.C.D. HCOOEtHCHOHOOCCOOHCO2CHOCH3(CH3CH2CO)2OCH3CH2COOK,加热6.( )A.B.C.D.CHOH3CCH2CH3COOHH3CCHCCH3COOHH3CCHCH3COOHH3COOHO+CH2(COOC2H5)2C2H5ONa7.( )A.B.C.D.C(COOC2H5)2OCH(COOC2H5)2OCH(COOC2H5)2OCOCH2COOC2H58. CH3CH2COOHBr2红PC2H5OH H+Zn,甲苯OHCHCOOC2H5CH3( )( )( )H3O+精选学习资料 - - - - - - - - - 名师归纳总结 - - - - - - -第 2 页，共 9 页A.B.C.D.CH3CH2COBrCH3CHCOOHBrBrCH2CH2COOHCH3CH2CHOCH3CHCOOC2H5BrCH3CHCOOC2H5CH2CH3CH3CHCOOHCH2CH3CH3CH2COOC2H5OOOO9.COCH3+ HCHO +NHHCl( )ACOH2CCH2N.HClBOHH2CCH3.HClNCCOHCCHN.HClCOH2CCH3.HClD10.( )( )CHO + HCHOOH稀HCHO浓OHA.B.C.D.CHOCHOCH2OHCHOCH2OHCH2OHCH2CH2OCH2OHCOOHCH2OHCH2OHCOOHCOOHCHOCH2OH( )( )OO过量CH2I2 Zn Ph3P=CH211.A.B.C.D.CH2CH2CH2CH2CH2OCH2CH2精选学习资料 - - - - - - - - - 名师归纳总结 - - - - - - -第 3 页，共 9 页( )( )( )OHH2NiNa2Cr2O7 H2SO4OH稀加热12.A.B.C.D.OHOHOHOHOOCOOHOOOOOHOOCH3CHCH2CH2CH2COOHOHH+加热13.( )CHCH2CH2CH2COOHH2CABCHCH2CH2COOHH3CHCCOOCH3DCH3CHCH2CH2CH2COHOO CCH2CH2CH2CHCH3OHOOHCH3COCl14.( )( )AlCl3A.B.C.D.OCOCH3OHCOCH3OHCOCH3O COCH3OHC OCH3OHCOCH3OC OCH3COCH3OCOCH3OCHO + CH3CHO稀NaOH15.( )A.B.C.D.OCHCHCHOOOHOCH3OCOHO( )( )NH3Br2-NaOH16.HCOClCH3H2C精选学习资料 - - - - - - - - - 名师归纳总结 - - - - - - -第 4 页，共 9 页A.B.C.D.HCONH2CH3H2CHCONH2CH3H2CHCH3H2CHCONH2CH3H2CNH2HNH2CH3H2CHCONHBrCH3H2CHBrCH3H2CHCH2H2CCONH2NHOOKOHNOO()17.( )A.B.C.D.NKOOOOOOOOHOHNHOOCH2BrCH2BrCH2OHCH2OH18.( )( )COOEtC2H5ONaCH3COOH/H2O稀NaOH-H2OH3O+, 加热A.B.C.D.OOHOCOOEtOOOOOOOOOHOHOOH( )OCHO+ Ac2OCH3CO2K19.精选学习资料 - - - - - - - - - 名师归纳总结 - - - - - - -第 5 页，共 9 页A.B.C.D.OCHOCH2COOHOCHCHCOOKOCHOHOOCH2COCHOCH2COOH( )20.O+ ClCH2COOEtt-BuOKt-BuOHA.B.C.D.OCOOEtHOCOOEtClCOOEtCOOEt( )( )( )21.ONHHCHCOCH3H2ONaOAc加热H2CA.B.C.D.CH3NCH3NCH3NCH3NCH3OCH2CH2CCH3OCH3NCH2CH2CCH3OCH3OCH2CH2CCH3OCH3NCH2CH2CCH3OCH3OCH3OHCH2CH2CCH3OCH3OCH2CH2CCH3OCH3OOH( )( )( )( )22.OOOEtOH,HLiAlH4EtONaCH2(COOEt)2SOCl2精选学习资料 - - - - - - - - - 名师归纳总结 - - - - - - -第 6 页，共 9 页A.B.C.D.OOOOOOOOOOOOCH2OHCH2OHCH2OHCH2OHCH2OHCH2OHCH2OHCH2OHCOOEtCOOEtCOOEtCOOEtCOOEtCOOEtCOOEtClCH2ClCH2OHCH2ClCH2ClCH2ClCH2OHCH2ClCH2Cl( )23.PhMgBrOH3OPBr3PPh3NaOHCHO( )( )( )A.B.C.D.PhCH2CH2OHPhCHCH3PhCHPhCHCH2OHCH2PhCH2CH2BrPhCHCH2BrBrPhCHCH3BrPh3PCHCH2PhPh3PCHCH2PhPPh3CH3CPhPPh3Ph3P CCH2PhBrCHCHCH2PhCHCHPhCHH2CCHCHPhCHCHCH3CCHPhPhCHCH2BrOHOHBr24.OH+ HCHO +(CH3)2NH( )A.B.C.D.OHCH2N(CH3)2OHCH2N(CH3)2OHCH2N(CH3)2OHCH2N(CH3)2(H3C)2NH2C精选学习资料 - - - - - - - - - 名师归纳总结 - - - - - - -第 7 页，共 9 页+COOCH3( )25.A.B.C.D.H3CH3CCOOCH3CH3H3CH3CCOOCH3CH3H3CH3CCOOCH3CH3H3CH3CCOOCH3CH326.( )CH2CHCH(CH3)2OHH+,加热A.B.C.D.CH2CHCH(CH3)CHCHCH(CH3)2CH2CH3CH2CH2CH(CH3)227.( )OHCH3CH3CH2CCl, AlCl3OA.B.C.D.OHCH3COCH2CH3OHCH3COCH2CH3OCH3COCH2CH3OHH2CCOCH2CH328.( )( )( )( )NHOOKOHC2H5OHBrCH2CH2CH2CH3NaOH H2O+A.B.C.NKOOOOOKOKNOOOHNCH2CH2CH2CH3OONHCH2CH2CH2CH3OOOHNHCH2CH2CH2CH3OONHCH2CH2CH2CH3COONaCOONaCH3CH2CH2CH2NH2COOHCOOHCH3CH2CH2CH2NH2COONaCOONaCH3CH2CH2CNH2O精选学习资料 - - - - - - - - - 名师归纳总结 - - - - - - -第 8 页，共 9 页D.OOONHCH2CH2CH2CH3OCH3CH2CH2CH2NH2COOHONaOCOONa29.O+CHCOCH3KOHKOHP(C6H5)3H2C( )( )H2CA.B.C.D.OOOOHOOHCH2CH2O30.( )COCH3+ ClCH2COEtONaOEtOHH+( )A.B.C.D.CH3OCOOC2H5CH3OCOOC2H5CH3OHCOOC2H5CH3COOC2H5ClCOCHCH2OHCH3CHCHOCH3CHCOOHCH3CH3H2CCOOHOH精选学习资料 - - - - - - - - - 名师归纳总结 - - - - - - -第 9 页，共 9 页