超轻水超轻水PPT宣传资料宣传资料Where is the Hunza Valley, Pakistan?Hunza - The Land of “Shangri-La”What is Unique About Hunza?The Ultar Glacier !Ultar Glacier Water Irrigates CropsHisao Wushiki, Nagoya University1975 Glaciological Expedition of NepalAh Ha Less DeuteriumThat is why they live longer! Pervasive mutagens known to adversely affect DNA Solar Radiation Low-level Background Radiation Free RadicalsDeuterium oxide is also pervasive and known to adversely affect DNA Generally thought to have an effect at concentrations higher than those found in nature (155 ppm) Mainstream researchers have overlooked long term effects of low-level deuterium oxide exposure Adverse effect of deuterium is coupled to radiation and other mutagens that lead to DNA damage Effect of Radiation on Aging in Mice These mice pictured above are all 14 months old. As young adults, nine mice were given sub-lethal doses of radiation and nine others were left as untreated controls. The control mice (left) are still sleek and vigorous at 14 months, while six of the irradiated mice have died and the remaining three show signs of extreme aging. Correlation between lifespan and the relative effectiveness of DNA repair in the cells of certain mammals In each case, cells growing in tissue culture were irradiated with ultraviolet light and then the efficiency with which they repaired their DNA was determined. SpeciesAverage lifespan, yrEffectiveness of DNA repair as measured by the amount of unscheduled synthesis (grains/nucleus)Human7050Elephant6047Cow3043Hamster426Rat313Mouse29Shrew18From the work of R. W. Hart and R. B. Setlow, 1974.Hitting the Aging Wall At the end of life DNA has been compromised. No method short of reordering all DNA will significantly extend life. Ionizing Radiation & DNA DegradationTwo Mechanisms of Strand Breakage Linked to Ionizing Radiation Hydrogen and Deuterium Bonds in DNA Deuterium has an effect on biological processes through the mechanism of hydrogen bonding. Hydrogen bonds major play a role in DNA structure and are responsible for the double DNA strand assuming a helical shape. The bonds created by a deuterium atom are stronger than for a normal hydrogen atom. Effect of Deuterium Exchange on Bond Strength for Common Organic GroupsDashed lines are hydrogen bonds. The greatest effect occurs when a deuterium atom directly participates in a hydrogen bond. Values shown are in kcal/mol.Percentage Increase in Hydrogen Bond Strength due to Deuterium ExchangeExchange of some hydrogen atoms have little effect such as those under Min H-Bond D-Exch. Others have a large effect such as those under Crit H-Bond D-Exch. The maximum effect occurs when all hydrogen atoms are exchanged. . Organic CompoundMin H-Bond D-Exch IncrCrit H-Bond D-Exch IncrMax H-Bond D-Exch IncrFormaldehyde-water3.75%17.50%31.25%Formamide-water0.66%7.75%15.04%Plausible Mechanisms for Deuteriums Role in Aging Deuterium Compromised DNA Repair Enzymes A large class of enzymes and proteins play a role DNA replication and repair and make extensive use of hydrogen bonds The protein p53 plays an especially significant rolePlausible Mechanisms for Deuteriums Role in AgingSlowing of DNA Replication Deuterium may inhibit enzymes such as DnaB, Primase, or polymase If these enzymes are inhibited the rate of DNA replication may be slowed when DNA is most susceptible to damage by radiation Plausible Mechanisms for Deuteriums Role in AgingBonding Site Inhibition of DNA Repair Complex enzymes detect breaks and rejoin DNA strands based upon specific bonding sites If deuterium is present in these sites, steric effects and increased bonding strength could inhibit DNA repairPlausible Mechanisms for Deuteriums Role in AgingDeuterium Compromised DNA Enzymes Could lead to errors in DNA code Could lead to errors in proteins coded by DNAPeople of the Hunza RegionTerraced Hunza Fields Irrigated by Glacier Water Containing Lower Levels of Deuterium People of the Hunza Region Based upon geography and altitude we can infer that the deuterium content of the Hunza region is at or below 133 ppm. True age of Hunza people is difficult to verify, but there is ample evidence to support the claim that the elderly people of the region are vigorous and long lived. Growing food with DDW is key because not all organic compounds will exchange deuterium for hydrogen quickly.Effectiveness of Consuming DDW -OH Group bonds to Carbon, Nitrogen, and Oxygen depending upon pH. Carbon is the strongest bond with little H/D Exchange Hydrophobic molecules will not undergo H/D Exchange.Inside of Cell Membrane is HydrophobicBase Pairs Inside of DNA are HydrophobicBase Pairs Inside of DNA are HydrophobicMaximum BenefitGrow Food HydroponicallyEffectiveness of Consuming DDWConclusions DDW does not change its chemical composition when digested and has a direct effect at the cellular level. Consumption of DDW can conceivably protect DNA from damage and assist DNA repair mechanisms, but it does not directly repair DNA. DDW consumption will not “rejuvenate” the body, but it may help to protect the body and enable it to function more efficiently. Additional InformationKirk B. Goodall1443 East Washington Blvd, #223Pasadena, CA 91104 USAPh: 818-653-1136Fx: 209-208-1905kgoodall2001yahoo.comhttp:/geocities.com/kgoodall2001/anti-aging