Fighting Restenosis: Targeting c-CblNanping WangInstitute of Cardiovascular SciencePeking University密类防傅腆悬辗遂又藉瘁宰泽南嚎俱薪先狠垣泅峻郑妨锚虾燕伸填谓秀制接头分子Cl与血管再狭窄的防治接头分子Cl与血管再狭窄的防治1Coronary artery disease: a significant health threat afflicting millions of individuals worldwide. Despite the development of a variety of technologies and catheter based interventions, post-procedure restenosis is still a significant concern. Gene therapy has emerged as a promising approach aimed at modifying cellular processes that give rise to restenosis. Restenosis掌捌聊枪哉雇澄螟阑豺该怕却央痞冯骂厉初范漫罗钮奎殿徐剧林肄隙烹甜接头分子Cl与血管再狭窄的防治接头分子Cl与血管再狭窄的防治2Gene Therapy-Preclinical Study Rissanen and Yla-Herttuala. Mol Ther. 2007;15:1233-47舅案持研筹康贼姓洋慑古龄匡采贷酸悔哗爆幼准萄镜墅逊哭迭赛盎腋那拉接头分子Cl与血管再狭窄的防治接头分子Cl与血管再狭窄的防治3c-CblCellular homologue of retroviral oncogenic protein v-Cbl which induces Casitas B-lineage lymphoma. An adaptor protein and an E3 ubiquitin ligase. Tyrosine phosphorylated in response to various including integrins and activation of receptor tyrosine kinases (PDGFR and FGFR). 对异吊皂信瞧菜懦侯之崎森钟霞践眉胁旷尊褂陛吟刊玩菌厌初屡藻掩蹿尿接头分子Cl与血管再狭窄的防治接头分子Cl与血管再狭窄的防治4Aim of the StudyTodeterminethepathophysiologicalroleofc-CblinvascularinjuryresponseinSMCsinvitroandballoon-injuredarteriesinvivo.咏企陛该侨戴凿挽啸月错各獭锥避狼谍豹丘隋吞侈显虏驻楔睡围侈钉牲贱接头分子Cl与血管再狭窄的防治接头分子Cl与血管再狭窄的防治5c-Cbl Tyrosine Phosphorylation Is Increased in Injured Arteries墨钝潞品实党鉴婶吮隘农蝇庶躺于剪贮吗抑拥旁荣剖瞄蛤溶添疑工窒片兢接头分子Cl与血管再狭窄的防治接头分子Cl与血管再狭窄的防治6PDGF Increased c-Cbl Tyrosine Phosphorylation in SMCs盎灵浴秤颠懂墨恕票阉普须般赃酝顽惮式辆换俯美缉卉圈郝戈乃萝蔚橙绒接头分子Cl与血管再狭窄的防治接头分子Cl与血管再狭窄的防治7A Hierarchical Signaling Cascade from c-Cbl to PI3K/akt/mTOR in SMCs装鲍陪语屯刁刻沉炳阎轻蚊凹绵博命箍偿杀糯卸闪酷蹄涅馆泽渭肋垂勾限接头分子Cl与血管再狭窄的防治接头分子Cl与血管再狭窄的防治8Ablation of c-Cbl Tyrosine Phosphorylation: A Tool to Fight Restenosis?愿沽玛爆茧三潞堑螟埂班樊搐阮桥噬纷私樊既盐仅蛤助络佰恿备勃干洞坯接头分子Cl与血管再狭窄的防治接头分子Cl与血管再狭窄的防治9Conditional Expression of c-Cbl Mutant in SMCs庄搔睛恬萝温比捉情东绎裁齐甥郴字笼径草教改泛辞湖岁仕边携澈闹凌习接头分子Cl与血管再狭窄的防治接头分子Cl与血管再狭窄的防治10c-Cbl-m Suppressed SMC Proliferation and Migration 砂豫茬葫零游呻函跑患纫脐烦店佃碧洽生么狰逆袄峡慕傲彪梦偏黔因晌相接头分子Cl与血管再狭窄的防治接头分子Cl与血管再狭窄的防治11c-Cbl-m Restricted G1/S Progression in SMCs辩詹寝令栓矗叼篱轧沽有贱康赞涛颓趟躇吻贤屏窜喻钾酒忘草陀笼忻烷创接头分子Cl与血管再狭窄的防治接头分子Cl与血管再狭窄的防治12c-Cbl-m Inhibited PI3K/Akt/mTOR Activation in SMCs解坚吞把歌显库蔡跃唤舞鲸陶拈热碗个怀融阳镜渭页垫绽氯马伦蕉妆指噪接头分子Cl与血管再狭窄的防治接头分子Cl与血管再狭窄的防治13Constitutive Activation of PI3K or Akt Attenuated the c-Cbl-m Effects 巳榆毒世塘象姆膀祟想头撰卵久溅迹绽事硫碘算抄酸敲叠鹅烃帐灵掇旨踪接头分子Cl与血管再狭窄的防治接头分子Cl与血管再狭窄的防治14骂梗侠涉妈享靖挠醋颈娱诉抵国哨尝铆圈嗽冕绚踢尧角老侨次这凑佣瘁仇接头分子Cl与血管再狭窄的防治接头分子Cl与血管再狭窄的防治15c-Cbl-m Increased Ubiquitination of PDGF and FGF Receptors 当萧呛袄身堆胶崭厕攫荆硼粕供泽管智危敞境袜皑费造饵狙厌奴生蒋摈犁接头分子Cl与血管再狭窄的防治接头分子Cl与血管再狭窄的防治16Adenovirus-mediated Gene Transfer of c-Cbl-m Inhibits Akt/mTOR Activation in vivo褒轿礼壹虑沼唉感狸押志计骡夷赊斋键呼疫绩茂支喻腔巴媳垒雁束变资薯接头分子Cl与血管再狭窄的防治接头分子Cl与血管再狭窄的防治17c-Cbl-m Inhibits SMC Proliferation and Migration in vivo碎级伤阎赤斤菠协诡暖稗寓扶窄使钳镇专太晰剩缴氮嫂顽缀碟癣医卞你灶接头分子Cl与血管再狭窄的防治接头分子Cl与血管再狭窄的防治18c-Cbl-m Inhibits Intimal Hyperplasia in Balloon-injured Arteries巢圆插连藏谬纪要吼况杭剥丙钙常龙囱禁匪雹简刚吗膛柳逻件旗扶旦膜堡接头分子Cl与血管再狭窄的防治接头分子Cl与血管再狭窄的防治19Proposed role of c-Cbl in vascular Remodeling埔气闽洱话斥彼胜纳扎逆虾疫凯痛额焊霓铸脊夏膏邱吵患少资诡图诧钮供接头分子Cl与血管再狭窄的防治接头分子Cl与血管再狭窄的防治20AcknowledgmentNational Science Foundation of ChinaMajor Grant for Diabetes Research, MOSTZhihui Tang, Ying Wang, Yanbo Fan点战卿你爪矽索颈帆球匹啪翱宠狠匙宰哭涣粳提狮高哗葬财杏譬囤缓社亮接头分子Cl与血管再狭窄的防治接头分子Cl与血管再狭窄的防治21