ApoptosisintheregulationofImmunecellsPart11234目录CONTENTApoptosisBcl-2Mcl-1BimApoptosisMcl-1Bcl-2BimApoptosisintheregulationofImmunecellsprogrammedcelldeath(PCD)Differentfromnecrosis(坏死）UniversalMcl-1BimBcl-2ApoptosisDispensableDivideinto2types:InhibitionofapoptosiscaspasePromoteapoptosischangemitochondrialmembranepermeabilityProapoptoticfactorreleaseregulatecelldeath(apoptosis)Oncogene(DamagetotheBcl-2genehasbeenidentifiedasacauseofanumberofcancers)UniversalBimApoptosisMcl-1Bcl-2mechanismstillnotclearItsBH1combineswiththeBH3ofPuma(akindofproteinwhichalsobelongstoBcl-2andpromoteapoptosis)andstopthecytochromeCrelaesefrommitochondrioncanstopapoptosiswhentheamountofPumaislow(becaiseofitsinstability)ApoptosisBcl-2Mcl-1BimActivatedBaxorinhibitedBcl-2orbothmakeBH3-onlyproteinbindingtotheBcl2proteintightlybindstotheBH3-onlyproteinwithBidlikeBH3domain,causingmitochondrialpathwayapoptosis.ConclusionPart2Activation-inducedCellDeath(AICD)Reference:1.Anti-apoptoticMcl-1iscriticalforthesurvivalandniche-fillingcapacityofFoxp3+regulatoryTcells2.ROITTSEssentialImmunology12thEditionCellmembrane:FasL+FasMitochondria:ImbalanceofBcl2Caspase3Caspase8CleavageofICAD-LCADCleavageofDNAFLIPthanksforlistening！