Cancer metastasisDesigner:S.G.C.chen8332海. 水. 正. 蓝. 作. 品NEXT What is metastasis?Designer:S.G.C.chen8332海. 水. 正. 蓝. 作. 品NEXT Cancer Stem Cells motivate and motivate and maintain the maintain the growth of growth of cancer cellscancer cellspotentialitypotentiality plasticityplasticity make them make them easy to easy to survivesurviveHypothesis of tumor metastasisThe phases of Cancer metastasisThe mechanism of cancer metastasisMalignant Tumor metastasis pathway The molecules in the metastasis The phasesphases of Cancer metastasis俞仁涛Invasion(侵犯)Intravasation（内渗）Extravasation（外渗）Designer:S.G.C.chen8332海. 水. 正. 蓝. 作. 品NEXT Invasion1.Stable cell movable cell 2.Protein expression3.Movement mechanismRelative genesDesigner:S.G.C.chen8332海. 水. 正. 蓝. 作. 品NEXT Designer:S.G.C.chen8332海. 水. 正. 蓝. 作. 品NEXT Intravasation1.Angiogenesis 2.Immune escape Designer:S.G.C.chen8332海. 水. 正. 蓝. 作. 品NEXT ExtravasationThe inverse process of invasionTHE PROCESS OF TUMOR METASTASISDesigner:S.G.C.chen8332海. 水. 正. 蓝. 作. 品NEXT Malignant Tumor metastasis pathway 恶性肿瘤常见的转移途径恶性肿瘤常见的转移途径Designer:S.G.C.chen8332海. 水. 正. 蓝. 作. 品NEXT Common metastasis pathway 1.lymphaticmetastasis淋巴淋巴道转移道转移2.hematogenousmetastasis血道血道转移转移3.implantationmetastasis种植种植性转移性转移Designer:S.G.C.chen8332海. 水. 正. 蓝. 作. 品NEXT Process ： cancer cell lymph vessel regional lymph node beyond lymph node hematogenousmetastasis1.LymphaticmetastasizeDesigner:S.G.C.chen8332海. 水. 正. 蓝. 作. 品NEXT 2.HematogenousmetastasisulunglunguliverliverDesigner:S.G.C.chen8332海. 水. 正. 蓝. 作. 品NEXT Metastasis pathway（1 1） Body vein lung Body vein lung（2 2） Portal vein liver Portal vein liver（3 3） pulmonary veins Total body （ brain 、 bone 、 kidney 、 adrenal glands ） Designer:S.G.C.chen8332海. 水. 正. 蓝. 作. 品NEXT 3.Implantation metastasis ChestCeliacPericardial cavityDesigner:S.G.C.chen8332海. 水. 正. 蓝. 作. 品NEXT Bioremediation生物治生物治疗疗uLow side effectsuWide rangeuClear goalDesigner:S.G.C.chen8332海. 水. 正. 蓝. 作. 品NEXT Mechanism of cell metastasisCell adhesion molecule(CAM)Degradation of extracellular matrixMotility of tumor cellsFormation of vessels Regulation of gene expressionImmunizationDesigner:S.G.C.chen8332海. 水. 正. 蓝. 作. 品NEXT Cell adhesion molecule(CAM)vCadherinvIntegrinsvSelectinvIgSFvothersDesigner:S.G.C.chen8332海. 水. 正. 蓝. 作. 品NEXT Degradation of extracellular matrix Designer:S.G.C.chen8332海. 水. 正. 蓝. 作. 品NEXT 丝氨酸蛋白酶类丝氨酸蛋白酶类 半胱氨酸蛋白酶类（半胱氨酸蛋白酶类（ Caspase家族）家族）天冬氨酸蛋白酶类天冬氨酸蛋白酶类 基质金属蛋白酶类（基质金属蛋白酶类（MMPs）Degradation of extracellular matrix vProteoiytic enzymes (蛋白水解酶蛋白水解酶)溶解溶解ECMECM是肿瘤侵袭和转移的是肿瘤侵袭和转移的天然屏障天然屏障Designer:S.G.C.chen8332海. 水. 正. 蓝. 作. 品NEXT Motility of tumor cells Motility types: Random movement Directional movement Motility factors:AutoecrineparacrineDesigner:S.G.C.chen8332海. 水. 正. 蓝. 作. 品NEXT Formation of vesselsTumor metastasis relys on the forming of vessels.Brief Introduction to Molecules in Cancer MetastasisThree SectionspTumour angiogenesisp DisaggregationpIntravasationDesigner:S.G.C.chen8332海. 水. 正. 蓝. 作. 品NEXT Tumour angiogenesis pTumour angiogenesis has laid the foundation for tumour survival and tumour metastasis .Designer:S.G.C.chen8332海. 水. 正. 蓝. 作. 品NEXT Tumour angiogenesis ActivatedGeneCytokines:VEGF&TNFAdhiesion moleculesDesigner:S.G.C.chen8332海. 水. 正. 蓝. 作. 品NEXT DisaggregationBroken downDesigner:S.G.C.chen8332海. 水. 正. 蓝. 作. 品NEXT DisaggregationUpaCathepsinsMMPsDesigner:S.G.C.chen8332海. 水. 正. 蓝. 作. 品NEXT DisaggregationDiminished adhesivenessProteolytic enzymesDisaggregationDesigner:S.G.C.chen8332海. 水. 正. 蓝. 作. 品NEXT IntravasationShape TransformationTGFMAPSNA1