大数据与SCI论文写作ICU大数据指的是所涉及的数据量规模巨大到无法通过人工，在合理时间内达到截取、管理、处理、并整理成为人类所能解读的信息。“大数据”时代已经降临，在商业、经济及其他领域中，决策将日益基于数据和分析而作出，而并非基于经验和直觉。-2012纽约时报Data-drivendecisionmakingLeoAnthonyCeli,RogerG.Mark,DavidJ.Stone,andRobertA.Montgomery“BigData”intheIntensiveCareUnit.ClosingtheDataLoop,AmericanJournalofRespiratoryandCriticalCareMedicine,Vol.187,No.11(2013),pp.1157-1160.ElysiumBigdata-criticalcareWhyusedatabase?efficientuseofresearchinvestments.UnethicalGreatergeneralizability(largeregistriesandadministrativedata)Primarydatacollectionistooonerous(5-or10-yrfollow-ups)morepreciseestimateofeffect(largesample)Examples Data SourcesSELECTING A DATA SOURCEData QualityTaxonomy of the QuestionMapping the Question to the DataData QualityBlackN,PayneM:Directoryofclinicaldatabases:Improvingandpromotingtheiruse.QualSafHealthCare2003;12:348352Taxonomy of the QuestionMyexperiencewithMIMIC-2publicresearcharchiveofdatacollectedfrompatientsinintensivecareunits（30000）Openaccess,freelyavailiable(http:/physionet.org/mimic2/)HighresolutionBethIsraelDeaconessMedicalCenter(Boston)TechnologyprovidedbyMIT.Latestversion:2001-2008AccesstoMIMIC-2Figure 1. Relationship between initial iCa (upper panel) and logit transformed mortality by using Lowess smoothing technique.ZhangZ,XuX,NiH,DengH(2014)PredictiveValueofIonizedCalciuminCriticallyIllPatients:AnAnalysisofaLargeClinicalDatabaseMIMICII.PLoSONE9(4):e95204.doi:10.1371/journal.pone.0095204http:/www.plosone.org/article/info:doi/10.1371/journal.pone.0095204Table 3. Multivariable logistic regression categorizing calcium values into intervals by using linear spline function.ZhangZ,XuX,NiH,DengH(2014)PredictiveValueofIonizedCalciuminCriticallyIllPatients:AnAnalysisofaLargeClinicalDatabaseMIMICII.PLoSONE9(4):e95204.doi:10.1371/journal.pone.0095204http:/www.plosone.org/article/info:doi/10.1371/journal.pone.0095204Table 4. Multivariable logistic regression categorizing calcium values into design variables.ZhangZ,XuX,NiH,DengH(2014)PredictiveValueofIonizedCalciuminCriticallyIllPatients:AnAnalysisofaLargeClinicalDatabaseMIMICII.PLoSONE9(4):e95204.doi:10.1371/journal.pone.0095204http:/www.plosone.org/article/info:doi/10.1371/journal.pone.0095204DatamanagementLongformatidyearsexincue-180050000181055001182060000280120001281122000282133000380030000381020000382010001Wideformatidsexinc80inc81inc82ue80ue81ue82-105000550060000102120002200330010030300020001000001MissingvaluesMultipleimputationtechniqueInmyhospital海泰电子病历系统SQL语言集合（http:/www.w3schools.com/sql/sql_like.asp）RelationaldatabaseThemed_eventstablecontainsinformationpertainingtothepatient,dosageandannotation.Theadditivestablecontainsinformationrelatedtotheadditiveswhichareincludedwiththedrugadministration.Thea_meddurationstablecontainsinformationaboutthetimeanddurationofthemedicationthed_meditemtablelinkstheothertablestogether.PublishedpaperwithHaitaiAsampleofplateletdistributionTakehomemessage大数据是信息时代的标志医疗信息的电子化将带来临床研究的变革利用好现有的信息资源服务于临床研究